Abstract
A systematic literature review and meta-analyses (where appropriate) were performed and the GRADE approach was used to update the previous American Academy of Sleep Medicine Practice Parameters on the treatment of intrinsic circadian rhythm sleep-wake disorders. Available data allowed for positive endorsement (at a second-tier degree of confi dence) of strategically timed melatonin (for the treatment of DSWPD, blind adults with N24SWD, and children/ adolescents with ISWRD and comorbid neurological disorders), and light therapy with or without accompanying behavioral interventions (adults with ASWPD, children/adolescents with DSWPD, and elderly with dementia). Recommendations against the use of melatonin and discrete sleep-promoting medications are provided for demented elderly patients, at a second- and fi rst-tier degree of confi dence, respectively. No recommendations were provided for remaining treatments/ populations, due to either insuffi cient or absent data. Areas where further research is needed are discussed.
Original language | English (US) |
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Pages (from-to) | 1199-1236 |
Number of pages | 38 |
Journal | Journal of Clinical Sleep Medicine |
Volume | 11 |
Issue number | 10 |
DOIs | |
State | Published - 2015 |
Externally published | Yes |
Keywords
- ASWPD
- Circadian rhythms
- DSWPD
- ISWRD
- N24SWD
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Neurology
- Clinical Neurology