Clinical utility of endorectal MRI-guided prostate biopsy: Preliminary experience

Adam J. Jung, Antonio C. Westphalen, John Kurhanewicz, Zhen J. Wang, Peter R. Carroll, Jeffry P. Simko, Fergus V. Coakley

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Purpose To investigate the potential clinical utility of endorectal MRI-guided biopsy in patients with known or suspected prostate cancer. Materials and Methods We prospectively recruited 24 men with known or suspected prostate cancer in whom MRI-guided biopsy was clinically requested after multiparametric endorectal MRI showed one or more appropriate targets. One to six 18-gauge biopsy cores were obtained from each patient. Transrectal ultrasound guided biopsy results and post MRI-guided biopsy complications were also recorded. Results MRI-guided biopsy was positive in 5 of 7 patients with suspected prostate cancer (including 2 of 4 with prior negative ultrasound-guided biopsies), in 8 of 12 with known untreated prostate cancer (including 5 where MRI-guided biopsy demonstrated a higher Gleason score than ultrasound guided biopsy results), and in 3 of 5 with treated cancer. MRI-guided biopsies had a significantly higher maximum percentage of cancer in positive cores when compared with ultrasound guided biopsy (mean of 37 ± 8% versus 13 ± 4%; P = 0.01). No serious postbiopsy complications occurred. Conclusion Our preliminary experience suggests endorectal MRI-guided biopsy may safely contribute to the management of patients with known or suspected prostate cancer by making a new diagnosis of malignancy, upgrading previously diagnosed disease, or diagnosing local recurrence.

Original languageEnglish (US)
Pages (from-to)314-323
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Issue number2
StatePublished - Aug 2014
Externally publishedYes


  • MR imaging
  • prostate biopsy
  • prostate cancer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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