Col2-GFP reporter mouse - A new tool to study skeletal development

Jae Y. Cho; T. Dawn Grant; Gregory P. Lunstrum; William A. Horton

doi:10.1002/ajmg.10230

Col2-GFP reporter mouse - A new tool to study skeletal development

Jae Y. Cho, T. Dawn Grant, Gregory P. Lunstrum, William A. Horton

Research output: Contribution to journal › Short survey › peer-review

14 Scopus citations

Abstract

Transgenic mice were generated that harbor a Col2-GFP reporter that marks chondrocytes and their immediate precursors during skeletal development. Cells engaged in chondrogenesis were identified by conventional fluorescence microscopy and confocal optical sectioning within their native environments in live embryos and in thick tissue slices. The use of these mice offers a novel approach for studying the role of chondrocytes in skeletal development.

Original language	English (US)
Pages (from-to)	251-253
Number of pages	3
Journal	American Journal of Medical Genetics - Seminars in Medical Genetics
Volume	106
Issue number	4
DOIs	https://doi.org/10.1002/ajmg.10230
State	Published - Dec 1 2001
Externally published	Yes

Keywords

Chondrocytes
Chondrogenesis
Confocal microscopy
Green fluorescent protein
Reporter mice
Skeletal development
Transgenic mice
Type II collagen

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1002/ajmg.10230

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title = "Col2-GFP reporter mouse - A new tool to study skeletal development",

abstract = "Transgenic mice were generated that harbor a Col2-GFP reporter that marks chondrocytes and their immediate precursors during skeletal development. Cells engaged in chondrogenesis were identified by conventional fluorescence microscopy and confocal optical sectioning within their native environments in live embryos and in thick tissue slices. The use of these mice offers a novel approach for studying the role of chondrocytes in skeletal development.",

keywords = "Chondrocytes, Chondrogenesis, Confocal microscopy, Green fluorescent protein, Reporter mice, Skeletal development, Transgenic mice, Type II collagen",

author = "Cho, {Jae Y.} and {Dawn Grant}, T. and Lunstrum, {Gregory P.} and Horton, {William A.}",

year = "2001",

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volume = "106",

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T1 - Col2-GFP reporter mouse - A new tool to study skeletal development

AU - Cho, Jae Y.

AU - Dawn Grant, T.

AU - Lunstrum, Gregory P.

AU - Horton, William A.

PY - 2001/12/1

Y1 - 2001/12/1

N2 - Transgenic mice were generated that harbor a Col2-GFP reporter that marks chondrocytes and their immediate precursors during skeletal development. Cells engaged in chondrogenesis were identified by conventional fluorescence microscopy and confocal optical sectioning within their native environments in live embryos and in thick tissue slices. The use of these mice offers a novel approach for studying the role of chondrocytes in skeletal development.

AB - Transgenic mice were generated that harbor a Col2-GFP reporter that marks chondrocytes and their immediate precursors during skeletal development. Cells engaged in chondrogenesis were identified by conventional fluorescence microscopy and confocal optical sectioning within their native environments in live embryos and in thick tissue slices. The use of these mice offers a novel approach for studying the role of chondrocytes in skeletal development.

KW - Chondrocytes

KW - Chondrogenesis

KW - Confocal microscopy

KW - Green fluorescent protein

KW - Reporter mice

KW - Skeletal development

KW - Transgenic mice

KW - Type II collagen

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U2 - 10.1002/ajmg.10230

DO - 10.1002/ajmg.10230

M3 - Short survey

C2 - 11891675

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SN - 0148-7299

VL - 106

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EP - 253

JO - American Journal of Medical Genetics - Seminars in Medical Genetics

JF - American Journal of Medical Genetics - Seminars in Medical Genetics

IS - 4

ER -

Col2-GFP reporter mouse - A new tool to study skeletal development

Abstract

Keywords

ASJC Scopus subject areas

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