TY - JOUR
T1 - Comparative analysis of sequence variation in gp116 and gp55 components of glycoprotein B of human cytomegalovirus
AU - Chou, Sunwen
N1 - Funding Information:
This work was supported by Department of Veterans Affairs research funds. Karen Dennison, Taylor Dunn, Marcia Kennedy, and Gail Marousek provided technical assistance. Sequence data from this article have been deposited with the EMBVGenbank Data Libraries under Accession Nos. M60924, M60925, M60926, M60927, M60929, M60931, M60932, M60933, M60934, M85228 and M85229.
PY - 1992/5
Y1 - 1992/5
N2 - Sequence variation in the gpl 16 component of cytomegalovirus envelope glycoprotein B was examined in 11 clinical strains and compared with variation in gp55. The peptide variation in gpl16 was found to be strongly clustered at codons 27-67, 44-460, and to a lesser extent at codons 181-194, 311-317, and 387-397. Strains adopted one of three to four peptide configurations at these loci, usually consistent with their gp55 sequence configuration. Two instances were observed of a sequence variation arising from recombination within gB. The limited, largely group-specific nature of variation in both gpl16 and gp55 facilitates functional and immunologic analyses.
AB - Sequence variation in the gpl 16 component of cytomegalovirus envelope glycoprotein B was examined in 11 clinical strains and compared with variation in gp55. The peptide variation in gpl16 was found to be strongly clustered at codons 27-67, 44-460, and to a lesser extent at codons 181-194, 311-317, and 387-397. Strains adopted one of three to four peptide configurations at these loci, usually consistent with their gp55 sequence configuration. Two instances were observed of a sequence variation arising from recombination within gB. The limited, largely group-specific nature of variation in both gpl16 and gp55 facilitates functional and immunologic analyses.
UR - http://www.scopus.com/inward/record.url?scp=0026652849&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026652849&partnerID=8YFLogxK
U2 - 10.1016/0042-6822(92)90771-G
DO - 10.1016/0042-6822(92)90771-G
M3 - Article
C2 - 1314465
AN - SCOPUS:0026652849
SN - 0042-6822
VL - 188
SP - 388
EP - 390
JO - Virology
JF - Virology
IS - 1
ER -