Comparison of different quantitative approaches to18F-fluoride PET scans

Winfried Brenner, Cheryl Vernon, Mark Muzi, David A. Mankoff, Jeanne M. Link, Ernest U. Conrad, Janet F. Eary

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


The aim of this study was to evaluate the relationship between 18F-fluoride bone metabolic measures obtained by nonlinear regression (NLR), Patlak analysis, and standardized uptake value (SUV) for a wide range of normal and pathologic bone conditions. In patients imaged twice, changes in metabolic rates were determined using the different quantitation methods. Methods: In 33 patients 2-51 mo after resection of a bone tumor of the limbs, a total of 42 dynamic PET scans were performed after injection of 250-350 MBq 18F-fluoride. SUV, fluoride bone influx rate obtained by Patlak analysis (KPat), and fluoride bone influx rate obtained by NLR (KNLR) were calculated in each patient for the bone graft, the contralateral normal side, and the spine, if within the field of view. Results: SUV ranged from 0.4 to 9.9, KPat from 0.0035 to 0.0742 mL/min/mL, and KNLR from 0.0027 to 0.0737 mL/min/mL. Significant linear correlations were found between KPat and KNLR (r 0.99), KPat and SUV (r = 0.95), and KNLR and SUV (r = 0.93). Eight patients have been imaged twice within 6 mo. Changes in metabolic values of the grafts were significantly correlated for KPat and K NLR (r = 0.96), KPat and SUV (r = 0.88), and K NLR and SUV (r = 0.79). The 95% ranges of normal change in limb bones were ±58.0% for SUV, ±23.0% for KPat, and ±20.2% for KNLR; the corresponding 95% ranges in the spine were ±8.6%, ±7.6%, and ±19.6%. Conclusion: The results of this study show that 18F-fluoride metabolic values as well as changes in bone metabolism measured by SUV and Patlak analysis were strongly correlated with NLR findings. The high 95% range of normal change of SUV in limb bones, however, indicates that this parameter is of limited value in areas with low metabolic activity. The range of spontaneous bone metabolic rate fluctuations presented in this study may be used as an estimate for assessing changes in bone metabolic activity, and the normal values for limb bones provide a basis for further studies on 18F-fluoride bone metabolism.

Original languageEnglish (US)
Pages (from-to)1493-1500
Number of pages8
JournalJournal of Nuclear Medicine
Issue number9
StatePublished - Sep 1 2004
Externally publishedYes


  • Bone metabolism
  • F-fluoride ion
  • Nonlinear regression
  • PET
  • Patlak graphical analysis
  • Standardized uptake value

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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