Comparison of EUS-guided versus percutaneous and transjugular approaches for the performance of liver biopsies

Asim Shuja, Ahmad Alkhasawneh, Andre Fialho, Andrea Fialho, Amal Shukri, Ciel Harris, Carmen Smotherman, Miguel Malespin, Silvio W. de Melo

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Background: Liver biopsy through endoscopic ultrasound (EUS)has become a novel approach for tissue acquisition. We aim to evaluate the adequacy of EUS-guided liver biopsies in comparison to those obtained through interventional radiology (IR)techniques. Methods: A retrospective single-center analysis was performed of all IR (transjugular or image-guided percutaneous)and EUS-guided liver biopsies performed at an academic medical center from January 2016 to January 2018. Patient demographics, histologic characteristics, and clinical outcomes were collected. Results: 152 procedures were included for analysis. 45% of liver biopsies were performed through EUS-guidance. The most common indication for liver biopsy was NASH fibrosis staging (n = 64). IR-guided biopsies contained a higher number of complete portal triads (13.6 vs. 10.8 p ≤ 0.01)while EUS-guided biopsies produced an increased total specimen length (4.6 cm vs. 3.6 cm p ≤ 0.01).47% of biopsy samples were fragmented with the majority of these (72%)occurring with EUS-guided procedures (p ≤ 0.01). IR-guided biopsies led to more complications in comparison to EUS-guided procedures (p = 0.03)Conclusion: Liver biopsies performed through EUS-guidance are comparable to IR-guided liver biopsies and may have an enhanced safety profile with acceptable tissue acquisition characteristics. Standardization of techniques and needles is needed for optimization of tissue sampling.

Original languageEnglish (US)
Pages (from-to)826-830
Number of pages5
JournalDigestive and Liver Disease
Issue number6
StatePublished - Jun 2019


  • Complications
  • Liver biopsy
  • Tissue adequacy

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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