Comparison of heparin and streptokinase in the treatment of venous thrombosis

J. M. Porter, A. J. Seaman, H. H. Common, J. Rösch, L. R. Eidemiller, A. D. Calhoun

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


Heparin or streptokinase was administered in a prospective randomized fashion to 50 patients with phlebographically confirmed venous thrombosis of the extremities of 14 days or less duration. A total of 49 patients completed the investigative protocol with 26 receiving heparin and 23 receiving streptokinase. All patients were evaluated with sequential phlebograms. Complete thrombolysis with restoration of venous valve function occurred in one of 26 patients receiving heparin and in six of 23 patients receiving streptokinase. Fifty per cent of the patients treated with streptokinase with a total duration of symptoms of three days or less achieved complete lysis. The total incidence of therapeutic complications was similar in the two groups, but was more severe in the streptokinase treated patients.

Original languageEnglish (US)
Pages (from-to)511-519
Number of pages9
JournalAmerican Surgeon
Issue number9
StatePublished - 1975
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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