Complexity analysis of arterial pressure during periods of abrupt hemodynamic changes

Roberto Hornero, Mateo Aboy, Carlos Gómez, Daniel S. Hagg, Charles R. Phillips

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


In this communication, we estimated the Lempel-Ziv complexity (LZC) on over 40 h of arterial blood pressure (ABP) recordings corresponding to 18 mechanically ventilated animal subjects. In this study, all subjects underwent a period of abrupt hemodynamic changes after an induced injury involving severe blood loss leading to hemorrhagic shock, followed by fluid resuscitation using either lactated ringers or 0.9% normal saline. The LZC metric experienced a statistically significant increase (p < 0.01) immediately following the induced injury and a statistically significant reduction following the administration of fluid therapy (p < 0.01). These results indicate that LZC of ABP may be useful as a dynamic metric to assess fluid responsiveness.

Original languageEnglish (US)
Pages (from-to)797-801
Number of pages5
JournalIEEE Transactions on Biomedical Engineering
Issue number2
StatePublished - Feb 2008


  • Arterial blood pressure (ABP)
  • Fluid responsiveness
  • Hemodynamic changes
  • Lempel-Ziv complexity (LZC)

ASJC Scopus subject areas

  • Biomedical Engineering


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