Concord grape juice supplementation and neurocognitive function in human aging

Robert Krikorian, Erin L. Boespflug, David E. Fleck, Amanda L. Stein, Jolynne D. Wightman, Marcelle D. Shidler, Sara Sadat-Hossieny

Research output: Contribution to journalArticlepeer-review

195 Scopus citations


Polyphenol compounds found in berry fruits, in particular flavonoids, have been associated with health benefits including improvement in cognition and neuronal function with aging. Concord grape juice contains polyphenols, including anthocyanins and flavanols, and previous research has shown improvement in a number of human health conditions with grape juice supplementation. In the current study, older adult subjects with mild cognitive impairment consumed Concord grape juice or placebo for 16 weeks and were administered assessments of memory function and brain activation pre- and postintervention. Participants who consumed grape juice showed reduced semantic interference on memory tasks. Relatively greater activation in anterior and posterior regions of the right hemisphere was also observed with functional magnetic resonance imaging in the grape juice treated subjects. These findings provide further evidence that Concord grape juice can enhance neurocognitive function in older adults with mild memory decline.

Original languageEnglish (US)
Pages (from-to)5736-5742
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Issue number23
StatePublished - Jun 13 2012
Externally publishedYes


  • Concord grape juice
  • aging
  • brain activation
  • memory
  • mild cognitive impairment

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)


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