TY - JOUR
T1 - Concurrent heavy metal exposures and idiopathic dilated cardiomyopathy
T2 - A case-control study from the katanga mining area of the Democratic Republic of Congo
AU - Malamba-Lez, Didier
AU - Tshala-Katumbay, Désire
AU - Bito, Virginie
AU - Rigo, Jean Michel
AU - Kyandabike, Richie Kipenge
AU - Yolola, Eric Ngoy
AU - Katchunga, Philippe
AU - Koba-Bora, Béatrice
AU - Ngoy-Nkulu, Dophra
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/5/1
Y1 - 2021/5/1
N2 - Blood and/or urine levels of 27 heavy metals were determined by ICPMS in 41 patients with dilated cardiomyopathy (DCM) and 29 presumably healthy subjects from the Katanga Copperbelt (KC), in the Democratic Republic of Congo (DRC). After adjusting for age, gender, education level, and renal function, DCM probability was almost maximal for blood concentrations above 0.75 and 150 µg/dL for arsenic and copper, respectively. Urinary concentrations above 1 for chromium, 20 for copper, 600 for zinc, 30 for selenium, 2 for cadmium, 0.2 for antimony, 0.5 for thallium, and 0.05 for uranium, all in µg/g of creatinine, were also associated with increased DCM probability. Concurrent and multiple exposures to heavy metals, well beyond permissible levels, are associated with increased probability for DCM. Study findings warrant screening for metal toxicity in case of DCM and prompt public health measures to reduce exposures in the KC, DRC.
AB - Blood and/or urine levels of 27 heavy metals were determined by ICPMS in 41 patients with dilated cardiomyopathy (DCM) and 29 presumably healthy subjects from the Katanga Copperbelt (KC), in the Democratic Republic of Congo (DRC). After adjusting for age, gender, education level, and renal function, DCM probability was almost maximal for blood concentrations above 0.75 and 150 µg/dL for arsenic and copper, respectively. Urinary concentrations above 1 for chromium, 20 for copper, 600 for zinc, 30 for selenium, 2 for cadmium, 0.2 for antimony, 0.5 for thallium, and 0.05 for uranium, all in µg/g of creatinine, were also associated with increased DCM probability. Concurrent and multiple exposures to heavy metals, well beyond permissible levels, are associated with increased probability for DCM. Study findings warrant screening for metal toxicity in case of DCM and prompt public health measures to reduce exposures in the KC, DRC.
KW - Environmental exposures
KW - Heavy metals
KW - Idiopathic dilated cardiomyopathy
KW - Katanga Copperbelt
UR - http://www.scopus.com/inward/record.url?scp=85105200630&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85105200630&partnerID=8YFLogxK
U2 - 10.3390/ijerph18094956
DO - 10.3390/ijerph18094956
M3 - Article
C2 - 34066615
AN - SCOPUS:85105200630
SN - 1661-7827
VL - 18
JO - International journal of environmental research and public health
JF - International journal of environmental research and public health
IS - 9
M1 - 4956
ER -