Contribution of a membrane estrogen receptor to the estrogenic regulation of body temperature and energy homeostasis

Troy A. Roepke, Martha A. Bosch, Elizabeth A. Rick, Benjamin Lee, Edward J. Wagner, Dana Seidlova-Wuttke, Wolfgang Wuttke, Thomas S. Scanlan, Oline K. Rønnekleiv, Martin J. Kelly

Research output: Contribution to journalArticlepeer-review

89 Scopus citations


The hypothalamus is a key region of the central nervous system involved in the control of homeostasis, including energy and core body temperature (Tc). 17β-Estradiol (E2) regulates Tc, in part, via actions in thebasalhypothalamusandpreoptic area. E2 primarily controlshypothalamicfunctions viathenuclear steroid receptors, estrogen receptor α/β. However, we have previously described an E2-responsive, Gq-coupled membrane receptor that reduces the postsynaptic inhibitory γ-aminobutyric acid-ergic tone and attenuates postovariectomy body weight gain in female guinea pigs through the administration of a selective Gq-mER ligand, STX.To determine the role of Gq-mER in regulating Tc, energy and bone homeostasis, ovariectomized female guinea pigs, implanted ip with temperature probes, were treated with STX or E2 for 7-8 wk. Tc was recorded for 4 wk,where as food intake and body weight were monitored daily. Bone density and fat accumulation were determined postmortem. Both E2 and STX significantly reduced Tc in the females compared with controls. STX, similar to E2, reduced food intake and fat accumulation and increased tibial bone density. Therefore, a Gq-mER-coupled signaling pathway appears to be involved in maintaining homeostatic functions and may constitute a novel therapeutic target for treatment of hypoestrogenic symptoms.

Original languageEnglish (US)
Pages (from-to)4926-4937
Number of pages12
Issue number10
StatePublished - Oct 2010

ASJC Scopus subject areas

  • Endocrinology


Dive into the research topics of 'Contribution of a membrane estrogen receptor to the estrogenic regulation of body temperature and energy homeostasis'. Together they form a unique fingerprint.

Cite this