Contribution of diminished ovarian reserve to hypofertility associated with endometriosis

D. L. Hock, K. Sharafi, L. Dagostino, E. Kemmann, D. B. Seifer

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


OBJECTIVE: To determine if ovarian reserve, as measured by day 3 levels Ed 2 and FSH, was different in patients with endometriosis as compared to controls. STUDY DESIGN: Case-control study of 75 women with laparoscopically staged endometriosis and 75 age-matched controls undergoing in vitro fertilization/embryo transfer for male factor infertility. RESULTS: In women with stage III/IV endometriosis (revised American Fertility Society staging), day 3 E 2 and FSH levels were significantly higher than control levels (51.9 pg/mL and 12.6 mIU/mL versus 34.7 pg/mL and 9.7 mIU/mL, P<.03). In contrast, women with stage I/II endometriosis did not differ significantly when compared to controls (36.8 pg/mL and 10.4 mIU/mL versus 34.0 pg/mL and 10.2 mIU/mL). The total group showed significantly higher E 2 levels (41.8 pg/mL versus 34.1 pg/mL, P<.03), but no significant differences in FSH levels were observed. CONCLUSION: These data show that women with stage III/IV endometriosis have relatively diminished ovarian reserve, while this situation is not noted in women with stage I/II endometriosis. This observation is consistent with progressive loss of ovarian reserve in women with increasing stages of endometriosis independent of age.

Original languageEnglish (US)
Pages (from-to)7-10
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number1
StatePublished - 2001


  • Endometriosis
  • Infertility
  • Male
  • Ovarian reserve
  • Ovary

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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