Contribution of neutrophils in the pathogenesis of rheumatoid arthritis

Lingshu Zhang, Yi Yuan, Qiang Xu, Zhengyu Jiang, Cong Qiu Chu

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Neutrophils are major innate immune effector cells for host defense and have been a topic of active research for their participation in the pathogenesis of autoimmune inflammatory diseases including rheumatoid arthritis (RA) due to recently discovered neutrophil extracellular trap (NET) formation. NET formation and other mechanisms leading to the release of neutrophil nuclear and cytoplasmic contents are implicated as a source of citrullinated antigens in RA. Further investigations are required to delineate what factors diverge neutrophils from host defense to autoimmune response in RA.

Original languageEnglish (US)
Article number0075
Pages (from-to)86-93
Number of pages8
JournalJournal of Biomedical Research
Issue number2
StatePublished - Apr 1 2020


  • NET formation
  • Neutrophils
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


Dive into the research topics of 'Contribution of neutrophils in the pathogenesis of rheumatoid arthritis'. Together they form a unique fingerprint.

Cite this