COPD and occupational exposures: A case-control study

Sheila Weinmann, William M. Vollmer, Victor Breen, Michael Heumann, Eva Hnizdo, Jacqueline Villnave, Brent Doney, Monica Graziani, Mary Ann McBurnie, A. Sonia Buist

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


OBJECTIVE: Evidence demonstrates that occupational exposures are causally linked with chronic obstructive pulmonary disease (COPD). This case-control study evaluated the association between occupational exposures and prevalent COPD based on lifetime occupational history. METHODS: Cases (n = 388) aged 45 years and older with COPD were compared with controls (n = 356), frequency matched on age, sex, and cigarette smoking history. Odds ratios for exposure to each of eight occupational hazard categories and three composite measures of exposure were computed using logistic regression. RESULTS: Occupational exposures most strongly associated with COPD were diesel exhaust, irritant gases and vapors, mineral dust, and metal dust. The composite measures describing aggregate exposure to gases, vapors, solvents, or sensitizers (GVSS) and aggregate exposure to dust, GVSS, or diesel exhaust were also associated with COPD. In the small group of never-smokers, a similar pattern was evident. CONCLUSION: These population-based findings add to the literature linking occupational exposures to COPD.

Original languageEnglish (US)
Pages (from-to)561-569
Number of pages9
JournalJournal of occupational and environmental medicine
Issue number5
StatePublished - May 2008

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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