COPD exacerbations: The importance of a standard definition

Romain Pauwels, P. Calverly, A. S. Buist, S. Rennard, Y. Fukuchi, E. Stahl, C. G. Löfdahl

Research output: Contribution to journalArticlepeer-review

119 Scopus citations


Efforts to assess the efficacy of new therapies in the treatment of acute exacerbations of chronic obstructive pulmonary disease (COPD) have been hampered by the lack of a widely agreed and consistently used definition. A variety of definitions have been used in clinical studies, based on changes in patient symptoms or the requirement for antibiotic therapy, oral steroids or hospitalisation. To date, none of these definitions have been assessed in detail for their reliability, responsiveness and validity determined. Considerable heterogeneity in the aetiology and manifestation of COPD exacerbations makes identification and quantification of defining symptoms extremely difficult. New approaches are therefore being sought with a view to identifying a serum or tissue marker that can be used as a valuable diagnostic tool. Improvements in data recording will also contribute to the accuracy of data retrieval and assessment. If we are to progress to a Level of sophistication seen in the diagnosis and management of other diseases, it is evident that considerable research efforts will be required to improve our understanding of COPD exacerbations and develop a standard definition for these events, thereby facilitating the assessment of therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)99-107
Number of pages9
JournalRespiratory Medicine
Issue number2
StatePublished - Feb 2004


  • COPD
  • Definition
  • Exacerbation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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