Coronary artery disease reporting and data system (CAD-RADS), vascular inflammation and plaque vulnerability

Daisuke Kinoshita; Keishi Suzuki; Haruhito Yuki; Takayuki Niida; Daichi Fujimoto; Yoshiyasu Minami; Damini Dey; Hang Lee; Iris McNulty; Junya Ako; Brian Ghoshhajra; Maros Ferencik; Tsunekazu Kakuta; Ik Kyung Jang

doi:10.1016/j.jcct.2023.09.008

Coronary artery disease reporting and data system (CAD-RADS), vascular inflammation and plaque vulnerability

Daisuke Kinoshita, Keishi Suzuki, Haruhito Yuki, Takayuki Niida, Daichi Fujimoto, Yoshiyasu Minami, Damini Dey, Hang Lee, Iris McNulty, Junya Ako, Brian Ghoshhajra, Maros Ferencik, Tsunekazu Kakuta, Ik Kyung Jang

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Coronary artery disease reporting and data system (CAD-RADS) predicts future cardiovascular events in patients with coronary artery disease (CAD). However, information on vascular inflammation and vulnerability remains scarce. Methods: Patients who underwent coronary computed tomography angiography (CTA) and optical coherence tomography (OCT) prior to coronary intervention were enrolled. All three coronary arteries were evaluated for CAD-RADS score and pericoronary adipose tissue (PCAT) attenuation, while the culprit vessel was analyzed for plaque vulnerability by OCT. Results: A total of 385 patients with 915 lesions were divided into two groups based on CAD-RADS score: 103 (26.8%) were categorized as CAD-RADS 4b/5 and 282 (73.2%) as CAD-RADS ≤4a. Patients with CAD-RADS 4b/5 had a higher level of PCAT attenuation (mean of 3 coronary arteries) than those with CAD-RADS ≤4a (−68.4 ± 6.7 HU vs. −70.1 ± 6.5, P = 0.022). The prevalence of macrophage was higher, and lipid index was greater in patients with CAD-RADS 4b/5 than CAD-RADS ≤4a (94.2% vs. 83.0%, P = 0.004, 1845 vs. 1477; P = 0.003). These associations were significant in the culprit vessels of patients with chronic coronary syndrome but not in those with acute coronary syndromes. Conclusions: Higher CAD-RADS score was associated with higher levels of vascular inflammation and plaque vulnerability.

Original language	English (US)
Pages (from-to)	445-452
Number of pages	8
Journal	Journal of Cardiovascular Computed Tomography
Volume	17
Issue number	6
DOIs	https://doi.org/10.1016/j.jcct.2023.09.008
State	Published - Nov 1 2023

Keywords

CAD-RADS
Optical coherence tomography
Pericoronary adipose tissue
Plaque burden
Vulnerable plaque

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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10.1016/j.jcct.2023.09.008

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Kinoshita, D., Suzuki, K., Yuki, H., Niida, T., Fujimoto, D., Minami, Y., Dey, D., Lee, H., McNulty, I., Ako, J., Ghoshhajra, B., Ferencik, M., Kakuta, T., & Jang, I. K. (2023). Coronary artery disease reporting and data system (CAD-RADS), vascular inflammation and plaque vulnerability. Journal of Cardiovascular Computed Tomography, 17(6), 445-452. https://doi.org/10.1016/j.jcct.2023.09.008

Kinoshita, D, Suzuki, K, Yuki, H, Niida, T, Fujimoto, D, Minami, Y, Dey, D, Lee, H, McNulty, I, Ako, J, Ghoshhajra, B, Ferencik, M, Kakuta, T & Jang, IK 2023, 'Coronary artery disease reporting and data system (CAD-RADS), vascular inflammation and plaque vulnerability', Journal of Cardiovascular Computed Tomography, vol. 17, no. 6, pp. 445-452. https://doi.org/10.1016/j.jcct.2023.09.008

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abstract = "Background: Coronary artery disease reporting and data system (CAD-RADS) predicts future cardiovascular events in patients with coronary artery disease (CAD). However, information on vascular inflammation and vulnerability remains scarce. Methods: Patients who underwent coronary computed tomography angiography (CTA) and optical coherence tomography (OCT) prior to coronary intervention were enrolled. All three coronary arteries were evaluated for CAD-RADS score and pericoronary adipose tissue (PCAT) attenuation, while the culprit vessel was analyzed for plaque vulnerability by OCT. Results: A total of 385 patients with 915 lesions were divided into two groups based on CAD-RADS score: 103 (26.8%) were categorized as CAD-RADS 4b/5 and 282 (73.2%) as CAD-RADS ≤4a. Patients with CAD-RADS 4b/5 had a higher level of PCAT attenuation (mean of 3 coronary arteries) than those with CAD-RADS ≤4a (−68.4 ± 6.7 HU vs. −70.1 ± 6.5, P = 0.022). The prevalence of macrophage was higher, and lipid index was greater in patients with CAD-RADS 4b/5 than CAD-RADS ≤4a (94.2% vs. 83.0%, P = 0.004, 1845 vs. 1477; P = 0.003). These associations were significant in the culprit vessels of patients with chronic coronary syndrome but not in those with acute coronary syndromes. Conclusions: Higher CAD-RADS score was associated with higher levels of vascular inflammation and plaque vulnerability.",

keywords = "CAD-RADS, Optical coherence tomography, Pericoronary adipose tissue, Plaque burden, Vulnerable plaque",

author = "Daisuke Kinoshita and Keishi Suzuki and Haruhito Yuki and Takayuki Niida and Daichi Fujimoto and Yoshiyasu Minami and Damini Dey and Hang Lee and Iris McNulty and Junya Ako and Brian Ghoshhajra and Maros Ferencik and Tsunekazu Kakuta and Jang, {Ik Kyung}",

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doi = "10.1016/j.jcct.2023.09.008",

language = "English (US)",

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T1 - Coronary artery disease reporting and data system (CAD-RADS), vascular inflammation and plaque vulnerability

AU - Kinoshita, Daisuke

AU - Suzuki, Keishi

AU - Yuki, Haruhito

AU - Niida, Takayuki

AU - Fujimoto, Daichi

AU - Minami, Yoshiyasu

AU - Dey, Damini

AU - Lee, Hang

AU - McNulty, Iris

AU - Ako, Junya

AU - Ghoshhajra, Brian

AU - Ferencik, Maros

AU - Kakuta, Tsunekazu

AU - Jang, Ik Kyung

PY - 2023/11/1

Y1 - 2023/11/1

N2 - Background: Coronary artery disease reporting and data system (CAD-RADS) predicts future cardiovascular events in patients with coronary artery disease (CAD). However, information on vascular inflammation and vulnerability remains scarce. Methods: Patients who underwent coronary computed tomography angiography (CTA) and optical coherence tomography (OCT) prior to coronary intervention were enrolled. All three coronary arteries were evaluated for CAD-RADS score and pericoronary adipose tissue (PCAT) attenuation, while the culprit vessel was analyzed for plaque vulnerability by OCT. Results: A total of 385 patients with 915 lesions were divided into two groups based on CAD-RADS score: 103 (26.8%) were categorized as CAD-RADS 4b/5 and 282 (73.2%) as CAD-RADS ≤4a. Patients with CAD-RADS 4b/5 had a higher level of PCAT attenuation (mean of 3 coronary arteries) than those with CAD-RADS ≤4a (−68.4 ± 6.7 HU vs. −70.1 ± 6.5, P = 0.022). The prevalence of macrophage was higher, and lipid index was greater in patients with CAD-RADS 4b/5 than CAD-RADS ≤4a (94.2% vs. 83.0%, P = 0.004, 1845 vs. 1477; P = 0.003). These associations were significant in the culprit vessels of patients with chronic coronary syndrome but not in those with acute coronary syndromes. Conclusions: Higher CAD-RADS score was associated with higher levels of vascular inflammation and plaque vulnerability.

AB - Background: Coronary artery disease reporting and data system (CAD-RADS) predicts future cardiovascular events in patients with coronary artery disease (CAD). However, information on vascular inflammation and vulnerability remains scarce. Methods: Patients who underwent coronary computed tomography angiography (CTA) and optical coherence tomography (OCT) prior to coronary intervention were enrolled. All three coronary arteries were evaluated for CAD-RADS score and pericoronary adipose tissue (PCAT) attenuation, while the culprit vessel was analyzed for plaque vulnerability by OCT. Results: A total of 385 patients with 915 lesions were divided into two groups based on CAD-RADS score: 103 (26.8%) were categorized as CAD-RADS 4b/5 and 282 (73.2%) as CAD-RADS ≤4a. Patients with CAD-RADS 4b/5 had a higher level of PCAT attenuation (mean of 3 coronary arteries) than those with CAD-RADS ≤4a (−68.4 ± 6.7 HU vs. −70.1 ± 6.5, P = 0.022). The prevalence of macrophage was higher, and lipid index was greater in patients with CAD-RADS 4b/5 than CAD-RADS ≤4a (94.2% vs. 83.0%, P = 0.004, 1845 vs. 1477; P = 0.003). These associations were significant in the culprit vessels of patients with chronic coronary syndrome but not in those with acute coronary syndromes. Conclusions: Higher CAD-RADS score was associated with higher levels of vascular inflammation and plaque vulnerability.

KW - CAD-RADS

KW - Optical coherence tomography

KW - Pericoronary adipose tissue

KW - Plaque burden

KW - Vulnerable plaque

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U2 - 10.1016/j.jcct.2023.09.008

DO - 10.1016/j.jcct.2023.09.008

M3 - Article

C2 - 37813721

AN - SCOPUS:85173229979

SN - 1934-5925

VL - 17

SP - 445

EP - 452

JO - Journal of Cardiovascular Computed Tomography

JF - Journal of Cardiovascular Computed Tomography

IS - 6

ER -

Coronary artery disease reporting and data system (CAD-RADS), vascular inflammation and plaque vulnerability

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