Correlates of lung/heart ratio of thallium-201 in coronary artery disese

S. Homma, S. Kaul, C. A. Boucher

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


We studied 306 patients with chest pain (262 with coronary artery disease and 44 with no coronary artery disease) to determine which of 23 clinical, exercise, thallium, and angiographic variables best discriminate between patients with increased lung/heart ratios of thallium versus those with normal ratios. Normal lung/heart ratio values were defined using an additional 45 subjects with <1% probability of coronary artery disease. The number of diseased vessels was the best discriminator between patients with increased ratios versus those with normal ratios. Double product at peak exercise, number of segments with abnormal wall motion, patient gender, and duration of exercise, were also significant discriminators. Using discriminant function analysis these variables could correctly identify 81% of cases with increased lung/heart ratios and 72% of cases with normal ratios. These results indicate that an increased lung/heart ratio of thallium reflects exercise-induced left ventricular dysfunction and affords a better understanding of why this thallium parameter is a powerful prognostic indicator in patients with chest pain.

Original languageEnglish (US)
Pages (from-to)1531-1535
Number of pages5
JournalJournal of Nuclear Medicine
Issue number10
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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