TY - JOUR
T1 - Correlation of early reduction in the apparent diffusion coefficient of water with blood flow reduction during middle cerebral artery occlusion in rats
AU - Mancuso, Anthony
AU - Karibe, Hiroshi
AU - Rooney, William D.
AU - Zarow, Gregory J.
AU - Graham, Steven H.
AU - Weiner, Michael W.
AU - Weinstein, Philip R.
PY - 1995/9
Y1 - 1995/9
N2 - To determine the relationship between reductions in the apparent diffusion coefficient of water (ADC) and in cerebral blood flow (CBF) during focal ischemia, we used diffusion‐weighted magnetic resonance (D‐MR) imaging and autoradiographic CBF analysis to examine rats subjected to 30 or 90 min of permanent middle cerebral artery (MCA) occlusion. In the 30‐min occlusion group (n = 10), the area with substantially reduced ADC (15% or more below the contralateral level [ADC15]) corresponded best to the area with CBF below 25 ml/100 g/min and was significantly smaller than the area with CBF below 50 ml/100 g/min (CBF50), a level associated with reduced protein synthesis and delayed necrosis (40 ± 13% versus 74 ± 8% of the ischemic hemisphere; P < 0.0001). In the 90‐min occlusion group (n = 6), the ADC15 area corresponded best to the CBF30 to CBF35 area and was again significantly smaller than the CBF50 area (54 ± 13% versus 73 ± 20%, P < 0.05). Thus, the area of substantially reduced ADC at 30 and 90 min represents only 53% and 74%, respectively, of the tissue at risk for infarction. These findings indicate a potential limitation in using early D‐MR imaging to predict stroke outcome.
AB - To determine the relationship between reductions in the apparent diffusion coefficient of water (ADC) and in cerebral blood flow (CBF) during focal ischemia, we used diffusion‐weighted magnetic resonance (D‐MR) imaging and autoradiographic CBF analysis to examine rats subjected to 30 or 90 min of permanent middle cerebral artery (MCA) occlusion. In the 30‐min occlusion group (n = 10), the area with substantially reduced ADC (15% or more below the contralateral level [ADC15]) corresponded best to the area with CBF below 25 ml/100 g/min and was significantly smaller than the area with CBF below 50 ml/100 g/min (CBF50), a level associated with reduced protein synthesis and delayed necrosis (40 ± 13% versus 74 ± 8% of the ischemic hemisphere; P < 0.0001). In the 90‐min occlusion group (n = 6), the ADC15 area corresponded best to the CBF30 to CBF35 area and was again significantly smaller than the CBF50 area (54 ± 13% versus 73 ± 20%, P < 0.05). Thus, the area of substantially reduced ADC at 30 and 90 min represents only 53% and 74%, respectively, of the tissue at risk for infarction. These findings indicate a potential limitation in using early D‐MR imaging to predict stroke outcome.
KW - cerebral blood flow
KW - diffusion‐weighted MRI
KW - focal cerebral ischemia
KW - rat
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U2 - 10.1002/mrm.1910340314
DO - 10.1002/mrm.1910340314
M3 - Article
C2 - 7500876
AN - SCOPUS:0029097337
SN - 0740-3194
VL - 34
SP - 368
EP - 377
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
IS - 3
ER -