TY - JOUR
T1 - Correlation of the average water diffusion constant with cerebral blood flow and ischemic damage after transient middle cerebral artery occlusion in cats
AU - Miyabe, Masayuki
AU - Mori, Susumu
AU - Van Zijl, Peter C.M.
AU - Kirsch, Jeffrey R.
AU - Eleff, Scott M.
AU - Koehler, Raymond C.
AU - Traystman, Richard J.
PY - 1996
Y1 - 1996
N2 - Magnetic resonance water diffusion imaging can detect early ischemic changes in stroke. Using a middle cerebral artery occlusion model, we examined which range of values of the orientation-independent diffusion quantity D(av) = 1/3Trace(D⇆) = 1/3(D(xx) + D(yy) + D(zz)) is an early noninvasive indicator of reduced cerebral perfusion and focal brain injury. Cats underwent either a 30-min occlusion followed by 3.5 h reperfusion (n = 7) or a 60-rain occlusion followed by 4-h reperfusion (n = 6). Repeated measurements of CBF were made with radiolabeled microspheres, and acute focal injury was measured with triphenyltetrazolium chloride (TTC) staining. During occlusion, the decrease in D(av) correlated with CBF for caudate [30=min occlusion (n = 13): p < 0.0001; 60-min occlusion (n = 6): p < 0.02] and for cortex [30-min occlusion (n = 12): p < 0.0001; 60-min occlusion (n = 5): p< 0.04]. Variable caudate and hemispheric injury levels were found among cats in both groups. The area of tissue injury demarcated by TTC began to correlate with the area of reduced D(av) by 30 min of occlusion (p < 0.02), and this correlation improved (p < 0.0001) at 1, 1.5, and 2.0 h after the onset of occlusion. The time necessary to reach a one-to-one correspondence between the percent of hemisphere injured and the percent of hemispheric area with D(av) < 0.65 x 10-9 m2/s was 2 h after occlusion. Thus, the absolute value of D(av) is a good indicator of the risk of tissue injury, whereas the combination of D(av) and the length of time of D(av) reduction is an excellent predictor of acute focal tissue injury demarcated by TTC staining.
AB - Magnetic resonance water diffusion imaging can detect early ischemic changes in stroke. Using a middle cerebral artery occlusion model, we examined which range of values of the orientation-independent diffusion quantity D(av) = 1/3Trace(D⇆) = 1/3(D(xx) + D(yy) + D(zz)) is an early noninvasive indicator of reduced cerebral perfusion and focal brain injury. Cats underwent either a 30-min occlusion followed by 3.5 h reperfusion (n = 7) or a 60-rain occlusion followed by 4-h reperfusion (n = 6). Repeated measurements of CBF were made with radiolabeled microspheres, and acute focal injury was measured with triphenyltetrazolium chloride (TTC) staining. During occlusion, the decrease in D(av) correlated with CBF for caudate [30=min occlusion (n = 13): p < 0.0001; 60-min occlusion (n = 6): p < 0.02] and for cortex [30-min occlusion (n = 12): p < 0.0001; 60-min occlusion (n = 5): p< 0.04]. Variable caudate and hemispheric injury levels were found among cats in both groups. The area of tissue injury demarcated by TTC began to correlate with the area of reduced D(av) by 30 min of occlusion (p < 0.02), and this correlation improved (p < 0.0001) at 1, 1.5, and 2.0 h after the onset of occlusion. The time necessary to reach a one-to-one correspondence between the percent of hemisphere injured and the percent of hemispheric area with D(av) < 0.65 x 10-9 m2/s was 2 h after occlusion. Thus, the absolute value of D(av) is a good indicator of the risk of tissue injury, whereas the combination of D(av) and the length of time of D(av) reduction is an excellent predictor of acute focal tissue injury demarcated by TTC staining.
KW - Brain injury
KW - Cerebral blood flow
KW - Magnetic resonance imaging
KW - Transient focal ischemia
KW - Water diffusion tensor trace
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U2 - 10.1097/00004647-199609000-00012
DO - 10.1097/00004647-199609000-00012
M3 - Article
C2 - 8784232
AN - SCOPUS:0029763518
SN - 0271-678X
VL - 16
SP - 881
EP - 891
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
IS - 5
ER -