TY - JOUR
T1 - Corrigendum
T2 - Synthetic torpor triggers a regulated mechanism in the rat brain, favoring the reversibility of Tau protein hyperphosphorylation (Frontiers in Physiology, (2023), 14, (1129278), 10.3389/fphys.2023.1129278)
AU - Squarcio, Fabio
AU - Hitrec, Timna
AU - Piscitiello, Emiliana
AU - Cerri, Matteo
AU - Giovannini, Catia
AU - Martelli, Davide
AU - Occhinegro, Alessandra
AU - Taddei, Ludovico
AU - Tupone, Domenico
AU - Amici, Roberto
AU - Luppi, Marco
N1 - Publisher Copyright:
Copyright © 2023 Squarcio, Hitrec, Piscitiello, Cerri, Giovannini, Martelli, Occhinegro, Taddei, Tupone, Amici and Luppi.
PY - 2023
Y1 - 2023
N2 - In the published article, there was an error in Figure 4E as published. The only histogram bars represented in Panel E left side (referred to P-Cx [i.e., Parietal cortex]) are wrong, together with the relative “y” scale. However, the representative Western blot bands depicted at the bottom of the histograms are correct, as described in the original caption that is also reported below. The corrected Figure 4 and its correct original caption appear below. Western blot detection of the main enzymes involved in phosphorylation and dephosphorylation of Tau, determined in brain extracts of the parietal cortex (P-Cx) and hippocampus (Hip). Below each histogram, WB representative samples are shown for each experimental condition. (A) glycogen-synthase kinase-3β (GSK3β), the main kinase targeting Tau; (B) p[S9]-GSK3β (inactive form of GSK3β, phosphorylated at Ser9); (C) protein phosphatase-2A (PP2A), the main phosphatase targeting Tau; (D) different isoforms of Akt (protein kinase-B; Akt 1/2/3), kinases targeting GSK3β at Ser9 and antiapoptotic factors; (E) p[S473] Akt, the active form of Akt 1/2/3, phosphorylated at Ser473. Data are normalized by β-actin and expressed as means ± S.E.M., n = 3. *: p < 0.05 vs. C. Experimental groups (see Figure 1): C, control; N, samples taken at nadir of hypothermia, during ST; ER, early recovery, samples taken when Tb reached 35.5°C following ST; R3, samples taken 3 h after ER; R6, samples taken 6 h after ER. The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
AB - In the published article, there was an error in Figure 4E as published. The only histogram bars represented in Panel E left side (referred to P-Cx [i.e., Parietal cortex]) are wrong, together with the relative “y” scale. However, the representative Western blot bands depicted at the bottom of the histograms are correct, as described in the original caption that is also reported below. The corrected Figure 4 and its correct original caption appear below. Western blot detection of the main enzymes involved in phosphorylation and dephosphorylation of Tau, determined in brain extracts of the parietal cortex (P-Cx) and hippocampus (Hip). Below each histogram, WB representative samples are shown for each experimental condition. (A) glycogen-synthase kinase-3β (GSK3β), the main kinase targeting Tau; (B) p[S9]-GSK3β (inactive form of GSK3β, phosphorylated at Ser9); (C) protein phosphatase-2A (PP2A), the main phosphatase targeting Tau; (D) different isoforms of Akt (protein kinase-B; Akt 1/2/3), kinases targeting GSK3β at Ser9 and antiapoptotic factors; (E) p[S473] Akt, the active form of Akt 1/2/3, phosphorylated at Ser473. Data are normalized by β-actin and expressed as means ± S.E.M., n = 3. *: p < 0.05 vs. C. Experimental groups (see Figure 1): C, control; N, samples taken at nadir of hypothermia, during ST; ER, early recovery, samples taken when Tb reached 35.5°C following ST; R3, samples taken 3 h after ER; R6, samples taken 6 h after ER. The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
KW - deep hypothermia
KW - glycogen synthase kinase 3β
KW - hippocampus
KW - melatonin
KW - microtubules
KW - parietal cortex
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U2 - 10.3389/fphys.2023.1256251
DO - 10.3389/fphys.2023.1256251
M3 - Comment/debate
AN - SCOPUS:85167334191
SN - 1664-042X
VL - 14
JO - Frontiers in Physiology
JF - Frontiers in Physiology
M1 - 1256251
ER -