Abstract
The present study showed that corticosterone (B) could induce a rapid activation of p38 and c-Jun NH2-terminal protein kinase (JNK) in PC12 cells. The dose-response and time-response curves were bell-shaped with maximal activation at 10-9 M and at 15 min. RU38486 had no effect, and bovine serum albumin-coupled B could induce the activation. Genistein failed to block the phosphorylation, suggesting the pathway was not involved in tyrosine kinase activity. Phorbol 12-myristate 13-acetate could mimic, while Gö6976 could abolish the actions. These results demonstrated that B might act via a putative membrane receptor to activate p38 and JNK rapidly through a protein kinase C-dependent pathway.
Original language | English (US) |
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Pages (from-to) | 210-214 |
Number of pages | 5 |
Journal | FEBS Letters |
Volume | 492 |
Issue number | 3 |
DOIs | |
State | Published - Mar 16 2001 |
Externally published | Yes |
Keywords
- Corticosterone
- Non-genomic
- PC12 cell
- Protein kinase C
- c-Jun NH-terminal protein kinase
- p38
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology