Corticotropin release during ECT in man

J. P. Allen, D. Denney, J. W. Kendall, P. H. Blachly

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Patterns of corticotropin (ACTH) secretion were studied following single and multiple electrically induced convulsions in the course of treating seven psychiatric patients. All seven patients improved clinically after administration of ECT along with other rehabilitative and therapeutic measures. The pattern of ACTH release during ECT was found to be similar to the pattern during other known physiological stresses. Serial seizures produced sustained high ACTH levels that fell to basal levels at the same rate as the fall after a single convulsion. One patient who had been receiving supraphysiological doses of steroids showed no rise in ACTH during five serial seizures. Clinical and heuristic implications of these results are discussed. (22 references.)

Original languageEnglish (US)
Pages (from-to)1225-1228
Number of pages4
JournalAmerican Journal of Psychiatry
Issue number11
StatePublished - 1974
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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