Corticotropin Releasing Factor (CRF) Activity in Rat Plasma (39468)

John W. Kendall; Daniel K. Gray; N. Donna Gaudette

doi:10.3181/00379727-152-39468

Corticotropin Releasing Factor (CRF) Activity in Rat Plasma (39468)

John W. Kendall, Daniel K. Gray, N. Donna Gaudette

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The ACTH-releasing activity of hypothalamic extract and rat plasma was examined with the dispersed rat pituitary cell technique of Swallow and Sayers (8). Although both plasma and serum caused ACTH release which was dose-related, stress did not enhance the ACTH releasing activity. Furthermore, separation studies of plasma using ultrafiltration and gel separation suggest that the CRF activity in plasma is associated with molecules of a molecular weight greater than 15,000. The hypothalamic extract used in this study was kindly provided by the National Institute of Arthritis, Metabolism and Digestive Diseases (NIAMDD) Rat Pituitary Hormone Distribution Program.

Original language	English (US)
Pages (from-to)	691-694
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	152
Issue number	4
DOIs	https://doi.org/10.3181/00379727-152-39468
State	Published - Sep 1976
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.3181/00379727-152-39468

Cite this

@article{1bebcce749374facae1b9b6924662a2d,

title = "Corticotropin Releasing Factor (CRF) Activity in Rat Plasma (39468)",

abstract = "The ACTH-releasing activity of hypothalamic extract and rat plasma was examined with the dispersed rat pituitary cell technique of Swallow and Sayers (8). Although both plasma and serum caused ACTH release which was dose-related, stress did not enhance the ACTH releasing activity. Furthermore, separation studies of plasma using ultrafiltration and gel separation suggest that the CRF activity in plasma is associated with molecules of a molecular weight greater than 15,000. The hypothalamic extract used in this study was kindly provided by the National Institute of Arthritis, Metabolism and Digestive Diseases (NIAMDD) Rat Pituitary Hormone Distribution Program.",

author = "Kendall, {John W.} and Gray, {Daniel K.} and Gaudette, {N. Donna}",

note = "Funding Information: Supported in part by Institutional Research Support from the Veterans Administration and by NIAMDD Grant AM01457. 2 ",

year = "1976",

month = sep,

doi = "10.3181/00379727-152-39468",

language = "English (US)",

volume = "152",

pages = "691--694",

journal = "Proceedings of the Society for Experimental Biology and Medicine",

issn = "0037-9727",

publisher = "SAGE Publications Ltd",

number = "4",

}

TY - JOUR

T1 - Corticotropin Releasing Factor (CRF) Activity in Rat Plasma (39468)

AU - Kendall, John W.

AU - Gray, Daniel K.

AU - Gaudette, N. Donna

N1 - Funding Information: Supported in part by Institutional Research Support from the Veterans Administration and by NIAMDD Grant AM01457. 2

PY - 1976/9

Y1 - 1976/9

N2 - The ACTH-releasing activity of hypothalamic extract and rat plasma was examined with the dispersed rat pituitary cell technique of Swallow and Sayers (8). Although both plasma and serum caused ACTH release which was dose-related, stress did not enhance the ACTH releasing activity. Furthermore, separation studies of plasma using ultrafiltration and gel separation suggest that the CRF activity in plasma is associated with molecules of a molecular weight greater than 15,000. The hypothalamic extract used in this study was kindly provided by the National Institute of Arthritis, Metabolism and Digestive Diseases (NIAMDD) Rat Pituitary Hormone Distribution Program.

AB - The ACTH-releasing activity of hypothalamic extract and rat plasma was examined with the dispersed rat pituitary cell technique of Swallow and Sayers (8). Although both plasma and serum caused ACTH release which was dose-related, stress did not enhance the ACTH releasing activity. Furthermore, separation studies of plasma using ultrafiltration and gel separation suggest that the CRF activity in plasma is associated with molecules of a molecular weight greater than 15,000. The hypothalamic extract used in this study was kindly provided by the National Institute of Arthritis, Metabolism and Digestive Diseases (NIAMDD) Rat Pituitary Hormone Distribution Program.

UR - http://www.scopus.com/inward/record.url?scp=0017052706&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017052706&partnerID=8YFLogxK

U2 - 10.3181/00379727-152-39468

DO - 10.3181/00379727-152-39468

M3 - Article

C2 - 1085936

AN - SCOPUS:0017052706

SN - 0037-9727

VL - 152

SP - 691

EP - 694

JO - Proceedings of the Society for Experimental Biology and Medicine

JF - Proceedings of the Society for Experimental Biology and Medicine

IS - 4

ER -

Corticotropin Releasing Factor (CRF) Activity in Rat Plasma (39468)

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this