Corticotropin-Releasing Factor Stimulation Test

Alan N. Elias, Grant Gwiniip, George P. Chrousos, Lynnette Nieman, Bruce Nisula, Gordon B. Cutler, D. Lynn Loriaux, Heinrich M. Schulte, Philip W. Gold, Edward H. Oldeield

Research output: Contribution to journalLetterpeer-review


To the Editor: 'The paper by Chrousos et al. on corlicolropinreleasing factor as an aid in the diagnosis of Cushing's disease (March 8 issue)1 fails to take into consideration the fact that the pituitary tumors responsible for Cushing's disease are not homogeneous. As shown by Lamberts et al., a major proportion of these tumors are rich in neural tissue and behave differently in response to provocative and inhibitory stimuli than do antcrior-lobc tumors.2 Such ACTH-sccreting ncurointermcdiate-lobc tumors are relatively refractory to glucocorticoid suppression but are suppressed by the dopamine agonist bromocriptine. We and others have found that possible neurointermediate-lobc tumors.

Original languageEnglish (US)
Pages (from-to)471-473
Number of pages3
JournalNew England Journal of Medicine
Issue number7
StatePublished - Aug 16 1984
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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