Corticotropin-releasing hormone: Clinical applications

L. K. Nieman, D. L. Loriaux

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Corticotropin-releasing hormone, a 41-amino-acid peptide, is an important hypothalamic factor regulating the pituitary secretion of adrenocorticotropic hormone (ACTH). This hormone, while rarely involved in the etiology of Cushing's syndrome, seems to play a major role in the pathogenesis of non-Cushing hypercortisolemic states. The administration of synthetic human and ovine CRH has been found useful in the differential diagnosis of Cushing's syndrome and in the preoperative localization of intrasellar ACTH-secreting tumors.

Original languageEnglish (US)
Pages (from-to)331-339
Number of pages9
JournalAnnual review of medicine
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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