TY - JOUR
T1 - Creutzfeldt-Jakob Disease in a Young Adult with Idiopathic Hypopituitarism
T2 - Possible Relation to the Administration of Cadaveric Human Growth Hormone
AU - Koch, Thomas K.
AU - Berg, Bruce O.
AU - de Armond, Stephen J.
AU - Gravina, Richard F.
PY - 1985/9/19
Y1 - 1985/9/19
N2 - CREUTZFELDT—JAKOB disease, a transmissible subacute degeneration of the central nervous system, is generally considered a disease of older adults.1 We recently evaluated a 20-year-old man with idiopathic hypopituitarism and insulin-dependent diabetes mellitus in whom Creutzfeldt—Jakob disease developed. Since early childhood he had received cadaveric human growth hormone, as well as insulin, thyroid hormone, and more recently testosterone. Case Report The patient, a 20-year-old man, was referred to the University of California, San Francisco, for evaluation of progressive gait instability. His history was complicated by multiple deficiencies of pituitary hormones from infancy, as well as insulin-dependent diabetes mellitus. Hypopituitarism was suggested.
AB - CREUTZFELDT—JAKOB disease, a transmissible subacute degeneration of the central nervous system, is generally considered a disease of older adults.1 We recently evaluated a 20-year-old man with idiopathic hypopituitarism and insulin-dependent diabetes mellitus in whom Creutzfeldt—Jakob disease developed. Since early childhood he had received cadaveric human growth hormone, as well as insulin, thyroid hormone, and more recently testosterone. Case Report The patient, a 20-year-old man, was referred to the University of California, San Francisco, for evaluation of progressive gait instability. His history was complicated by multiple deficiencies of pituitary hormones from infancy, as well as insulin-dependent diabetes mellitus. Hypopituitarism was suggested.
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U2 - 10.1056/NEJM198509193131206
DO - 10.1056/NEJM198509193131206
M3 - Article
C2 - 3897861
AN - SCOPUS:0022363507
SN - 0028-4793
VL - 313
SP - 731
EP - 733
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 12
ER -