TY - JOUR
T1 - Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis
AU - Banda, Nirmal K.
AU - Bernier, Jacques
AU - Kurahara, David K.
AU - Kurrle, Roland
AU - Haigwood, Nancy
AU - Sekaly, Rafik P.
AU - Finkel, Terri Helman
PY - 1992/10/1
Y1 - 1992/10/1
N2 - During human immunodeficiency virus (HIV) infection there is a profound and selective decrease in the CD4+ population of T lymphocytes. The mechanism of this depletion is not understood, as only a small fraction of all CD4+ cells appear to be productively infected with HIV-1 in seropositive individuals. In the present study, crosslinking of bound gp120 on human CD4+ T cells followed by signaling through the T cell receptor for antigen was found to result in activation-dependent cell death by a form of cell suicide termed apoptosis, or programmed cell death. The data indicate that even picomolar concentrations of gp120 prime T cells for activation-induced cell death, suggesting a mechanism for CD4+ T cell depletion in acquired immune deficiency syndrome (AIDS), particularly in the face of concurrent infection and antigenic challenge with other organisms. These results also provide an explanation for the enhancement of infection by certain antibodies against HIV, and for the paradox that HIV appears to cause AIDS after the onset of antiviral immunity.
AB - During human immunodeficiency virus (HIV) infection there is a profound and selective decrease in the CD4+ population of T lymphocytes. The mechanism of this depletion is not understood, as only a small fraction of all CD4+ cells appear to be productively infected with HIV-1 in seropositive individuals. In the present study, crosslinking of bound gp120 on human CD4+ T cells followed by signaling through the T cell receptor for antigen was found to result in activation-dependent cell death by a form of cell suicide termed apoptosis, or programmed cell death. The data indicate that even picomolar concentrations of gp120 prime T cells for activation-induced cell death, suggesting a mechanism for CD4+ T cell depletion in acquired immune deficiency syndrome (AIDS), particularly in the face of concurrent infection and antigenic challenge with other organisms. These results also provide an explanation for the enhancement of infection by certain antibodies against HIV, and for the paradox that HIV appears to cause AIDS after the onset of antiviral immunity.
UR - http://www.scopus.com/inward/record.url?scp=0026784923&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026784923&partnerID=8YFLogxK
M3 - Article
C2 - 1402655
AN - SCOPUS:0026784923
SN - 0022-1007
VL - 176
SP - 1099
EP - 1106
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 4
ER -