@article{40176aaab6ae4a9891053f2d44c6a635,
title = "Crosstalk between ROR1 and the Pre-B Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia",
abstract = "We report that t(1;19) ALL cells universally exhibit expression of and dependence on the cell surface receptor ROR1. We further identify t(1;19) ALL cell sensitivity to the kinase inhibitor dasatinib due to its inhibition of the pre-B cell receptor (pre-BCR) signaling complex. These phenotypes are a consequence of developmental arrest at an intermediate/late stage of B-lineage maturation. Additionally, inhibition of pre-BCR signaling induces further ROR1 upregulation, and we identify distinct ROR1 and pre-BCR downstream signaling pathways that are modulated in a counterbalancing manner-both leading to AKT phosphorylation. Consistent with this, AKT phosphorylation is transiently eliminated after dasatinib treatment, but is partially restored following dasatinib potentiation of ROR1 expression. Consequently, ROR1 silencing accentuates dasatinib killing of t(1;19) ALL cells.",
author = "Bicocca, {Vincent T.} and Chang, {Bill H.} and Masouleh, {Behzad Kharabi} and Markus Muschen and Loriaux, {Marc M.} and Druker, {Brian J.} and Tyner, {Jeffrey W.}",
note = "Funding Information: We thank Cristina Tognon for helpful review of this manuscript. Patient samples from the Children{\textquoteright}s Oncology Group were obtained through a collaboration with the COG ALL Cell Bank (Proposal #2008-08) J.W.T. is supported by grants from the William Lawrence and Blanche Hughes Fund, the Leukemia & Lymphoma Society, the National Cancer Institute (Grant 4R00CA151457-03), and the Oregon Clinical and Translational Research Institute (Grant UL1 RR024140 from the National Center for Research Resources, a component of the NIH, and NIH Roadmap for Medical Research). B.H.C. is supported by grants from the Oregon Child Health Research Center and by St. Baldricks Foundation. B.J.D. is an investigator of the Howard Hughes Medical Institute. ",
year = "2012",
month = nov,
day = "13",
doi = "10.1016/j.ccr.2012.08.027",
language = "English (US)",
volume = "22",
pages = "656--667",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "5",
}