CSF α-MSH in dementia of the Alzheimer type

I. Rainero, C. May, J. A. Kaye, R. P. Friedland, S. I. Rapoport

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


We measured CSF a-melanocyte stimulating hormone-like immunoreactivity (a-MSH-LI) in 35 patients with dementia of the Alzheimer type (DAT) and in 27 healthy control subjects. Mean a-MSH-LI concentration was significantly decreased in DAT patients as compared with age-matched controls. However, when the DAT patients were analyzed according to age at onset of dementia or presence of extrapyramidal signs, α-MSH-LI concentrations remained significantly lower than in controls only in DAT patients with late onset of dementia (>65 years of age). No correlation was found between a-MSH levels and degree of mental impairment. A significant negative correlation was found between CSF concentrations of a-MSH and homovanillic acid in the group of all DAT patients (p < 0.001). These results suggest that hypothalamic neurons which produce pro-opiornelanocortin -related peptides may be involved in Alzheimer’s disease.

Original languageEnglish (US)
Pages (from-to)1281-1284
Number of pages4
Issue number8
StatePublished - Aug 1988
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


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