TY - JOUR
T1 - Current progress with primate embryonic stem cells.
AU - Byrne, James A.
AU - Mitalipov, Shoukhrat M.
AU - Wolf, Don P.
PY - 2006/5
Y1 - 2006/5
N2 - Embryonic stem cells (ESCs) can proliferate indefinitely, maintain an undifferentiated pluripotent state and differentiate into any cell type. Differentiation of ESCs into various specific cell-types may be able to cure or alleviate the symptoms of various degenerative diseases. Unresolved issues regarding maintaining function, possible apoptosis and tumor formation in vivo mean a prudent approach should be taken towards advancing ESCs into human clinical trials. Rhesus macaques provide the ideal model organism for testing the feasibility, efficacy and safety of ESC based therapies and significant numbers of primate ESC lines are now available. In this review, we will summarize progress in evaluating the genetic and epigenetic integrity of primate ESCs, examine their current use in pre-clinical trials and discuss the potential of producing ESC-derived cell populations that are genetically identical (isogenic) to the host by somatic cell nuclear transfer.
AB - Embryonic stem cells (ESCs) can proliferate indefinitely, maintain an undifferentiated pluripotent state and differentiate into any cell type. Differentiation of ESCs into various specific cell-types may be able to cure or alleviate the symptoms of various degenerative diseases. Unresolved issues regarding maintaining function, possible apoptosis and tumor formation in vivo mean a prudent approach should be taken towards advancing ESCs into human clinical trials. Rhesus macaques provide the ideal model organism for testing the feasibility, efficacy and safety of ESC based therapies and significant numbers of primate ESC lines are now available. In this review, we will summarize progress in evaluating the genetic and epigenetic integrity of primate ESCs, examine their current use in pre-clinical trials and discuss the potential of producing ESC-derived cell populations that are genetically identical (isogenic) to the host by somatic cell nuclear transfer.
UR - http://www.scopus.com/inward/record.url?scp=36448970284&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36448970284&partnerID=8YFLogxK
U2 - 10.2174/157488806776956913
DO - 10.2174/157488806776956913
M3 - Review article
C2 - 18220862
AN - SCOPUS:36448970284
SN - 1574-888X
VL - 1
SP - 127
EP - 138
JO - Current stem cell research & therapy
JF - Current stem cell research & therapy
IS - 2
ER -