Cutaneous responses to vaccinia in individuals with previous smallpox vaccination

Eric L. Simpson, Michelle Hercher, Erika K. Hammarlund, Matthew W. Lewis, Mark K. Slifka, Jon Hanifin

    Research output: Contribution to journalArticlepeer-review

    9 Scopus citations


    The durability of immune responses to smallpox vaccine is a subject of considerable debate. We compared cutaneous vaccinia responses in patients vaccinated in the distant past with vaccine-naïve individuals using serial close-up photographs. The previously vaccinated group had a significantly reduced time course and milder cutaneous reactions. Vaccinated individuals appear to maintain clinically detectable immunity against vaccinia for at least 20 years after smallpox vaccination.

    Original languageEnglish (US)
    Pages (from-to)442-444
    Number of pages3
    JournalJournal of the American Academy of Dermatology
    Issue number3
    StatePublished - Sep 2007

    ASJC Scopus subject areas

    • Dermatology


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