Cutaneous responses to vaccinia in individuals with previous smallpox vaccination

Eric L. Simpson; Michelle Hercher; Erika K. Hammarlund; Matthew W. Lewis; Mark K. Slifka; Jon M. Hanifin

doi:10.1016/j.jaad.2007.04.022

Cutaneous responses to vaccinia in individuals with previous smallpox vaccination

Eric L. Simpson, Michelle Hercher, Erika K. Hammarlund, Matthew W. Lewis, Mark K. Slifka, Jon M. Hanifin

Oregon National Primate Research Center

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The durability of immune responses to smallpox vaccine is a subject of considerable debate. We compared cutaneous vaccinia responses in patients vaccinated in the distant past with vaccine-naïve individuals using serial close-up photographs. The previously vaccinated group had a significantly reduced time course and milder cutaneous reactions. Vaccinated individuals appear to maintain clinically detectable immunity against vaccinia for at least 20 years after smallpox vaccination.

Original language	English (US)
Pages (from-to)	442-444
Number of pages	3
Journal	Journal of the American Academy of Dermatology
Volume	57
Issue number	3
DOIs	https://doi.org/10.1016/j.jaad.2007.04.022
State	Published - Sep 2007

ASJC Scopus subject areas

Dermatology

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10.1016/j.jaad.2007.04.022

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title = "Cutaneous responses to vaccinia in individuals with previous smallpox vaccination",

abstract = "The durability of immune responses to smallpox vaccine is a subject of considerable debate. We compared cutaneous vaccinia responses in patients vaccinated in the distant past with vaccine-na{\"i}ve individuals using serial close-up photographs. The previously vaccinated group had a significantly reduced time course and milder cutaneous reactions. Vaccinated individuals appear to maintain clinically detectable immunity against vaccinia for at least 20 years after smallpox vaccination.",

author = "Simpson, {Eric L.} and Michelle Hercher and Hammarlund, {Erika K.} and Lewis, {Matthew W.} and Slifka, {Mark K.} and Hanifin, {Jon M.}",

year = "2007",

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T1 - Cutaneous responses to vaccinia in individuals with previous smallpox vaccination

AU - Simpson, Eric L.

AU - Hercher, Michelle

AU - Hammarlund, Erika K.

AU - Lewis, Matthew W.

AU - Slifka, Mark K.

AU - Hanifin, Jon M.

PY - 2007/9

Y1 - 2007/9

N2 - The durability of immune responses to smallpox vaccine is a subject of considerable debate. We compared cutaneous vaccinia responses in patients vaccinated in the distant past with vaccine-naïve individuals using serial close-up photographs. The previously vaccinated group had a significantly reduced time course and milder cutaneous reactions. Vaccinated individuals appear to maintain clinically detectable immunity against vaccinia for at least 20 years after smallpox vaccination.

AB - The durability of immune responses to smallpox vaccine is a subject of considerable debate. We compared cutaneous vaccinia responses in patients vaccinated in the distant past with vaccine-naïve individuals using serial close-up photographs. The previously vaccinated group had a significantly reduced time course and milder cutaneous reactions. Vaccinated individuals appear to maintain clinically detectable immunity against vaccinia for at least 20 years after smallpox vaccination.

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JF - Journal of the American Academy of Dermatology

IS - 3

ER -

Cutaneous responses to vaccinia in individuals with previous smallpox vaccination

Abstract

ASJC Scopus subject areas

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