Cyclooxygenase-2 gene expression in human breast cancer

Michelle L. Parkett, Randall E. Harris, Farahnaz S. Joarder, Mary S. Ross, Kathryn P. Clausen, Fredika M. Robertson

Research output: Contribution to journalArticlepeer-review

257 Scopus citations


Expression of the inducible isoform of the cyclooxygenase gene (PGHS-2, COX-2) which codes for the enzyme that catalyzes formation of prostaglandins, was detected in 13/13 human breast tumors of high grade but not in samples of normal breast tissue. There was a statistically significant linear association between COX-2 gene expression and high (>50%) tumor cell density (p < 0.01), with COX-2 protein localized to tumor cells. These results indicate that COX-2 gene expression may be useful as a molecular biomarker for human breast tumors and may also predict sensitivity to treatment with nonsteroidal anti-inflammatory drugs.

Original languageEnglish (US)
Pages (from-to)503-507
Number of pages5
JournalInternational Journal of Oncology
Issue number3
StatePublished - Mar 1997
Externally publishedYes


  • COX-2
  • breast cancer
  • cyclooxygenase
  • nonsteroidal anti-inflammatory drugs

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Cyclooxygenase-2 gene expression in human breast cancer'. Together they form a unique fingerprint.

Cite this