Cyclosporine nephrotoxicity

Emmanuel A. Burdmann; Takeshi F. Andoh; Luis Yu; William M. Bennett

doi:10.1016/S0270-9295(03)00090-1

Cyclosporine nephrotoxicity

Emmanuel A. Burdmann, Takeshi F. Andoh, Luis Yu, William M. Bennett

Research output: Contribution to journal › Article › peer-review

235 Scopus citations

Abstract

After more than 20 years of cyclosporine use its nephrotoxicity remains a significant clinical problem. Cyclosporine-induced renal injury has been described in solid organs recipients and in patients treated for autoimmune diseases. It is manifested in 2 distinct and well characterized forms, acute nephrotoxicity and chronic nephrotoxicity. This communication reviews the current literature analyzing the available data about the pathogenesis and mechanisms of acute and chronic cyclosporine-induced nephrotoxicity. A working hypothesis for the possible mechanisms of chronic cyclosporine nephrotoxicity will be provided.

Original language	English (US)
Pages (from-to)	465-476
Number of pages	12
Journal	Seminars in nephrology
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/S0270-9295(03)00090-1
State	Published - Sep 2003
Externally published	Yes

ASJC Scopus subject areas

Nephrology

Access to Document

10.1016/S0270-9295(03)00090-1

Cite this

@article{e043c488d4b14340b4f66687a94c95c7,

title = "Cyclosporine nephrotoxicity",

abstract = "After more than 20 years of cyclosporine use its nephrotoxicity remains a significant clinical problem. Cyclosporine-induced renal injury has been described in solid organs recipients and in patients treated for autoimmune diseases. It is manifested in 2 distinct and well characterized forms, acute nephrotoxicity and chronic nephrotoxicity. This communication reviews the current literature analyzing the available data about the pathogenesis and mechanisms of acute and chronic cyclosporine-induced nephrotoxicity. A working hypothesis for the possible mechanisms of chronic cyclosporine nephrotoxicity will be provided.",

author = "Burdmann, {Emmanuel A.} and Andoh, {Takeshi F.} and Luis Yu and Bennett, {William M.}",

year = "2003",

month = sep,

doi = "10.1016/S0270-9295(03)00090-1",

language = "English (US)",

volume = "23",

pages = "465--476",

journal = "Seminars in Nephrology",

issn = "0270-9295",

publisher = "W.B. Saunders Ltd",

number = "5",

}

TY - JOUR

T1 - Cyclosporine nephrotoxicity

AU - Burdmann, Emmanuel A.

AU - Andoh, Takeshi F.

AU - Yu, Luis

AU - Bennett, William M.

PY - 2003/9

Y1 - 2003/9

N2 - After more than 20 years of cyclosporine use its nephrotoxicity remains a significant clinical problem. Cyclosporine-induced renal injury has been described in solid organs recipients and in patients treated for autoimmune diseases. It is manifested in 2 distinct and well characterized forms, acute nephrotoxicity and chronic nephrotoxicity. This communication reviews the current literature analyzing the available data about the pathogenesis and mechanisms of acute and chronic cyclosporine-induced nephrotoxicity. A working hypothesis for the possible mechanisms of chronic cyclosporine nephrotoxicity will be provided.

AB - After more than 20 years of cyclosporine use its nephrotoxicity remains a significant clinical problem. Cyclosporine-induced renal injury has been described in solid organs recipients and in patients treated for autoimmune diseases. It is manifested in 2 distinct and well characterized forms, acute nephrotoxicity and chronic nephrotoxicity. This communication reviews the current literature analyzing the available data about the pathogenesis and mechanisms of acute and chronic cyclosporine-induced nephrotoxicity. A working hypothesis for the possible mechanisms of chronic cyclosporine nephrotoxicity will be provided.

UR - http://www.scopus.com/inward/record.url?scp=0141869674&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141869674&partnerID=8YFLogxK

U2 - 10.1016/S0270-9295(03)00090-1

DO - 10.1016/S0270-9295(03)00090-1

M3 - Article

C2 - 13680536

AN - SCOPUS:0141869674

SN - 0270-9295

VL - 23

SP - 465

EP - 476

JO - Seminars in Nephrology

JF - Seminars in Nephrology

IS - 5

ER -

Cyclosporine nephrotoxicity

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this