Cyclosporine nephrotoxicity

Emmanuel A. Burdmann, Takeshi F. Andoh, Luis Yu, William M. Bennett

Research output: Contribution to journalArticlepeer-review

235 Scopus citations


After more than 20 years of cyclosporine use its nephrotoxicity remains a significant clinical problem. Cyclosporine-induced renal injury has been described in solid organs recipients and in patients treated for autoimmune diseases. It is manifested in 2 distinct and well characterized forms, acute nephrotoxicity and chronic nephrotoxicity. This communication reviews the current literature analyzing the available data about the pathogenesis and mechanisms of acute and chronic cyclosporine-induced nephrotoxicity. A working hypothesis for the possible mechanisms of chronic cyclosporine nephrotoxicity will be provided.

Original languageEnglish (US)
Pages (from-to)465-476
Number of pages12
JournalSeminars in nephrology
Issue number5
StatePublished - Sep 2003
Externally publishedYes

ASJC Scopus subject areas

  • Nephrology


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