Cytomegaloviral hypophysitis in a simian immunodeficiency virus-infected rhesus macaque (Macacca mulatta)

Melissa R. Berg; Michael A. Owston; Marie Claire Gauduin; Basel T. Assaf; Anne D. Lewis; Edward J. Dick

doi:10.1111/jmp.12289

Cytomegaloviral hypophysitis in a simian immunodeficiency virus-infected rhesus macaque (Macacca mulatta)

Melissa R. Berg, Michael A. Owston, Marie Claire Gauduin, Basel T. Assaf, Anne D. Lewis, Edward J. Dick

Oregon National Primate Research Center

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Rhesus macaques experimentally infected with Simian Immunodeficiency Virus (SIV) experience immunosuppression and often opportunistic infection. Among the most common opportunistic infections are rhesus cytomegalovirus (RhCMV), a ubiquitous betaherpesvirus that undergoes continuous low-level replication in immunocompetent monkeys. Upon SIV-mediated immunodeficiency, RhCMV reactivates and results in lesions in numerous organ systems including the nervous and reproductive systems. We report the first case of cytomegaloviral hypophysitis in a SIV-immunocompromised rhesus macaque.

Original language	English (US)
Pages (from-to)	364-367
Number of pages	4
Journal	Journal of medical primatology
Volume	46
Issue number	6
DOIs	https://doi.org/10.1111/jmp.12289
State	Published - Dec 2017

Keywords

cytomegalovirus
inclusions
intra-cytoplasmic
intranuclear
model
non-human primate
pituitary
viral

ASJC Scopus subject areas

Animal Science and Zoology
General Veterinary

Access to Document

10.1111/jmp.12289

Cite this

@article{ff04ada7f2134815aad3024d2b32369b,

title = "Cytomegaloviral hypophysitis in a simian immunodeficiency virus-infected rhesus macaque (Macacca mulatta)",

abstract = "Rhesus macaques experimentally infected with Simian Immunodeficiency Virus (SIV) experience immunosuppression and often opportunistic infection. Among the most common opportunistic infections are rhesus cytomegalovirus (RhCMV), a ubiquitous betaherpesvirus that undergoes continuous low-level replication in immunocompetent monkeys. Upon SIV-mediated immunodeficiency, RhCMV reactivates and results in lesions in numerous organ systems including the nervous and reproductive systems. We report the first case of cytomegaloviral hypophysitis in a SIV-immunocompromised rhesus macaque.",

keywords = "cytomegalovirus, inclusions, intra-cytoplasmic, intranuclear, model, non-human primate, pituitary, viral",

author = "Berg, {Melissa R.} and Owston, {Michael A.} and Gauduin, {Marie Claire} and Assaf, {Basel T.} and Lewis, {Anne D.} and Dick, {Edward J.}",

note = "Publisher Copyright: {\textcopyright} 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",

year = "2017",

month = dec,

doi = "10.1111/jmp.12289",

language = "English (US)",

volume = "46",

pages = "364--367",

journal = "Journal of medical primatology",

issn = "0047-2565",

publisher = "Blackwell Munksgaard",

number = "6",

}

TY - JOUR

T1 - Cytomegaloviral hypophysitis in a simian immunodeficiency virus-infected rhesus macaque (Macacca mulatta)

AU - Berg, Melissa R.

AU - Owston, Michael A.

AU - Gauduin, Marie Claire

AU - Assaf, Basel T.

AU - Lewis, Anne D.

AU - Dick, Edward J.

PY - 2017/12

Y1 - 2017/12

N2 - Rhesus macaques experimentally infected with Simian Immunodeficiency Virus (SIV) experience immunosuppression and often opportunistic infection. Among the most common opportunistic infections are rhesus cytomegalovirus (RhCMV), a ubiquitous betaherpesvirus that undergoes continuous low-level replication in immunocompetent monkeys. Upon SIV-mediated immunodeficiency, RhCMV reactivates and results in lesions in numerous organ systems including the nervous and reproductive systems. We report the first case of cytomegaloviral hypophysitis in a SIV-immunocompromised rhesus macaque.

AB - Rhesus macaques experimentally infected with Simian Immunodeficiency Virus (SIV) experience immunosuppression and often opportunistic infection. Among the most common opportunistic infections are rhesus cytomegalovirus (RhCMV), a ubiquitous betaherpesvirus that undergoes continuous low-level replication in immunocompetent monkeys. Upon SIV-mediated immunodeficiency, RhCMV reactivates and results in lesions in numerous organ systems including the nervous and reproductive systems. We report the first case of cytomegaloviral hypophysitis in a SIV-immunocompromised rhesus macaque.

KW - cytomegalovirus

KW - inclusions

KW - intra-cytoplasmic

KW - intranuclear

KW - model

KW - non-human primate

KW - pituitary

KW - viral

UR - http://www.scopus.com/inward/record.url?scp=85021740067&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021740067&partnerID=8YFLogxK

U2 - 10.1111/jmp.12289

DO - 10.1111/jmp.12289

M3 - Article

C2 - 28671330

AN - SCOPUS:85021740067

SN - 0047-2565

VL - 46

SP - 364

EP - 367

JO - Journal of medical primatology

JF - Journal of medical primatology

IS - 6

ER -

Cytomegaloviral hypophysitis in a simian immunodeficiency virus-infected rhesus macaque (Macacca mulatta)

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this