Dental Stem Cells and Their Sources

Christine M. Sedgley; Tatiana M. Botero

doi:10.1016/j.cden.2012.05.004

Dental Stem Cells and Their Sources

Christine M. Sedgley, Tatiana M. Botero

School of Dentistry

Research output: Contribution to journal › Review article › peer-review

68 Scopus citations

Abstract

The search for more accessible mesenchymal stem cells than those found in bone marrow has propelled interest in dental tissues. Human dental stem/progenitor cells (collectively termed dental stem cells [DSCs]) that have been isolated and characterized include dental pulp stem cells, stem cells from exfoliated deciduous teeth, stem cells from apical papilla, periodontal ligament stem cells, and dental follicle progenitor cells. Common characteristics of these cell populations are the capacity for self-renewal and the ability to differentiate into multiple lineages. In vitro and animal studies have shown that DSCs can differentiate into osseous, odontogenic, adipose, endothelial, and neural-like tissues.

Original language	English (US)
Pages (from-to)	549-561
Number of pages	13
Journal	Dental Clinics of North America
Volume	56
Issue number	3
DOIs	https://doi.org/10.1016/j.cden.2012.05.004
State	Published - Jul 2012

Keywords

Dental follicle precursor cells (DFPCs)
Dental pulp stem cells (DPSCs)
Periodontal ligament stem cells (PDLSCs)
Stem cells from human exfoliated deciduous teeth (SHED cells)
Stem cells from root apical papilla (SCAP cells)

ASJC Scopus subject areas

Dentistry(all)

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10.1016/j.cden.2012.05.004

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title = "Dental Stem Cells and Their Sources",

abstract = "The search for more accessible mesenchymal stem cells than those found in bone marrow has propelled interest in dental tissues. Human dental stem/progenitor cells (collectively termed dental stem cells [DSCs]) that have been isolated and characterized include dental pulp stem cells, stem cells from exfoliated deciduous teeth, stem cells from apical papilla, periodontal ligament stem cells, and dental follicle progenitor cells. Common characteristics of these cell populations are the capacity for self-renewal and the ability to differentiate into multiple lineages. In vitro and animal studies have shown that DSCs can differentiate into osseous, odontogenic, adipose, endothelial, and neural-like tissues.",

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AU - Sedgley, Christine M.

AU - Botero, Tatiana M.

PY - 2012/7

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N2 - The search for more accessible mesenchymal stem cells than those found in bone marrow has propelled interest in dental tissues. Human dental stem/progenitor cells (collectively termed dental stem cells [DSCs]) that have been isolated and characterized include dental pulp stem cells, stem cells from exfoliated deciduous teeth, stem cells from apical papilla, periodontal ligament stem cells, and dental follicle progenitor cells. Common characteristics of these cell populations are the capacity for self-renewal and the ability to differentiate into multiple lineages. In vitro and animal studies have shown that DSCs can differentiate into osseous, odontogenic, adipose, endothelial, and neural-like tissues.

AB - The search for more accessible mesenchymal stem cells than those found in bone marrow has propelled interest in dental tissues. Human dental stem/progenitor cells (collectively termed dental stem cells [DSCs]) that have been isolated and characterized include dental pulp stem cells, stem cells from exfoliated deciduous teeth, stem cells from apical papilla, periodontal ligament stem cells, and dental follicle progenitor cells. Common characteristics of these cell populations are the capacity for self-renewal and the ability to differentiate into multiple lineages. In vitro and animal studies have shown that DSCs can differentiate into osseous, odontogenic, adipose, endothelial, and neural-like tissues.

KW - Dental follicle precursor cells (DFPCs)

KW - Dental pulp stem cells (DPSCs)

KW - Periodontal ligament stem cells (PDLSCs)

KW - Stem cells from human exfoliated deciduous teeth (SHED cells)

KW - Stem cells from root apical papilla (SCAP cells)

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JO - Dental Clinics of North America

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Dental Stem Cells and Their Sources

Abstract

Keywords

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