TY - JOUR
T1 - Dermatologic immune restoration syndrome
T2 - Report of five cases from a tertiary care center in North India
AU - Handa, Sanjeev
AU - Narang, Tarun
AU - Wanchu, Ajay
PY - 2008
Y1 - 2008
N2 - Background: Dermatologic conditions are often an early clue to human immunodeficiency virus (HIV) infection. As the disease progresses and the host immunity fails, patients may develop a number of skin conditions. At this point, they have a dominant T helper 2 immunologic response. After the initiation of antiretroviral therapy, the T helper 1 response is restored, and some skin problems, paradoxically, make their appearance then. Conclusion: Herpes zoster, mucocutaneous herpes, eosinophilic folliculitis, and mycobacterial infections have been known to occur at this stage. This may be because immune restoration of a host's immunity causes recognition of silent or latent infection and results in development of the condition. We report five cases that were seen at our center during a 2-year period.
AB - Background: Dermatologic conditions are often an early clue to human immunodeficiency virus (HIV) infection. As the disease progresses and the host immunity fails, patients may develop a number of skin conditions. At this point, they have a dominant T helper 2 immunologic response. After the initiation of antiretroviral therapy, the T helper 1 response is restored, and some skin problems, paradoxically, make their appearance then. Conclusion: Herpes zoster, mucocutaneous herpes, eosinophilic folliculitis, and mycobacterial infections have been known to occur at this stage. This may be because immune restoration of a host's immunity causes recognition of silent or latent infection and results in development of the condition. We report five cases that were seen at our center during a 2-year period.
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U2 - 10.2310/7750.2008.07017
DO - 10.2310/7750.2008.07017
M3 - Article
C2 - 18544296
AN - SCOPUS:63049085268
SN - 1203-4754
VL - 12
SP - 126
EP - 132
JO - Journal of Cutaneous Medicine and Surgery
JF - Journal of Cutaneous Medicine and Surgery
IS - 3
ER -