Dermatomyositis as a presentation of neuromyelitis optica spectrum disorder

David Delman, Xianming Peng, Daniel C. Zedek, Valerie Jewells, Nizar Chahin, Silva Markovic-Plese

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Importance: This is the first report of neuromyelitis optica spectrum disorder (NMOSD) associated with dermatomyositis (DM). Report: A 40. year-old Caucasian female presented with 6. months of worsening fatigue, rash, acute weakness worse in her lower extremities, and urinary retention. She was found to have both NMOSD and anti-melanoma differentiation-associated gene (MDA)5 positive DM with interstitial lung disease (ILD). She was treated aggressively and she regained her ability to ambulate. Conclusion: We recommend considering NMOSD in the differential diagnosis of patients with DM and other autoimmune disorders that also present with clinical signs of myelopathy.

Original languageEnglish (US)
Pages (from-to)108-111
Number of pages4
JournalJournal of Neuroimmunology
StatePublished - Jan 15 2015
Externally publishedYes


  • Dermatomyositis
  • MDA5 antibody
  • Neuromyelitis optica

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


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