Descemet membrane endothelial keratoplasty in complex eyes

Aazim Siddiqui, Winston D. Chamberlain

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Purpose of reviewTo review the current literature on Descemet membrane endothelial keratoplasty (DMEK) in complex eyes.Recent findingsDMEK surgery has become a standardized procedure in Fuchs endothelial dystrophy and simple bullous keratopathy. But eyes with more complex disease present unique intraoperative and postoperative challenges to the DMEK surgeon. Poor visualization during surgery, complex anterior segment anatomy, altered anterior chamber dynamics, glaucoma shunts, and congenital or iatrogenic missing or altered iris and lens make DMEK surgery extremely difficult to accomplish.SummaryDMEK is feasible in complex eyes, including advanced bullous keratopathy, eyes with history of glaucoma or vitreoretinal surgery, previous penetrating keratoplasty, uveitis, pediatric, and congenital anterior segment disorders. The tools and methods reported in the literature to accomplish DMEK in complex eyes vary widely with no particular consensus or standardization of techniques. The outcomes noted for some of these conditions demonstrate the difficulty of the surgery and the uncertainty of long-term graft survival in complex eyes. Both surgical standardization and randomized prospective data will better help elucidate DMEK's role in the corneal rehabilitation of complex eyes.

Original languageEnglish (US)
Pages (from-to)324-331
Number of pages8
JournalCurrent opinion in ophthalmology
Issue number4
StatePublished - Jul 1 2022


  • DMEK
  • PKP
  • aniridia
  • aphakia
  • avitric
  • bullous keratopathy
  • failed
  • glaucoma

ASJC Scopus subject areas

  • Ophthalmology


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