Detection of ultrasound-modulated photons and enhancement with ultrasound microbubbles

David J. Hall; Mark J. Hsu; Sadik Esener; Robert F. Mattrey

doi:10.1117/12.808603

Detection of ultrasound-modulated photons and enhancement with ultrasound microbubbles

David J. Hall, Mark J. Hsu, Sadik Esener, Robert F. Mattrey

Research output: Contribution to journal › Conference article › peer-review

7 Scopus citations

Abstract

In vivo acousto-optic imaging promises to provide optical contrast at superior ultrasound spatial resolution. The main challenge is to detect ultrasound-modulated photons in the overwhelming presence of un-modulated photons. We have demonstrated in vitro detection of ultrasound-modulated photons with a variety of detection methods. Furthermore, we have detected ultrasound-modulated fluorescence offering potential for acousto-optic molecular imaging. Moreover, we have demonstrated the use of ultrasound microbubbles to significantly enhance the acousto-optic signal at the ultrasound frequency with the additional generation of higher order harmonic frequencies. Here the results from our various detection methods, ultrasound-modulated fluorescence, and enhancement with microbubbles are presented.

Original language	English (US)
Article number	71771L
Journal	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	7177
DOIs	https://doi.org/10.1117/12.808603
State	Published - 2009
Externally published	Yes
Event	Photons Plus Ultrasound: Imaging and Sensing 2009 - San Jose, CA, United States Duration: Jan 25 2009 → Jan 28 2009

Keywords

Acousto-optic
Fluorescence
Microbubbles
Ultrasound-modulated photons

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

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10.1117/12.808603

Cite this

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title = "Detection of ultrasound-modulated photons and enhancement with ultrasound microbubbles",

abstract = "In vivo acousto-optic imaging promises to provide optical contrast at superior ultrasound spatial resolution. The main challenge is to detect ultrasound-modulated photons in the overwhelming presence of un-modulated photons. We have demonstrated in vitro detection of ultrasound-modulated photons with a variety of detection methods. Furthermore, we have detected ultrasound-modulated fluorescence offering potential for acousto-optic molecular imaging. Moreover, we have demonstrated the use of ultrasound microbubbles to significantly enhance the acousto-optic signal at the ultrasound frequency with the additional generation of higher order harmonic frequencies. Here the results from our various detection methods, ultrasound-modulated fluorescence, and enhancement with microbubbles are presented.",

keywords = "Acousto-optic, Fluorescence, Microbubbles, Ultrasound-modulated photons",

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year = "2009",

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volume = "7177",

journal = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

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note = "Photons Plus Ultrasound: Imaging and Sensing 2009 ; Conference date: 25-01-2009 Through 28-01-2009",

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T1 - Detection of ultrasound-modulated photons and enhancement with ultrasound microbubbles

AU - Hall, David J.

AU - Hsu, Mark J.

AU - Esener, Sadik

AU - Mattrey, Robert F.

PY - 2009

Y1 - 2009

N2 - In vivo acousto-optic imaging promises to provide optical contrast at superior ultrasound spatial resolution. The main challenge is to detect ultrasound-modulated photons in the overwhelming presence of un-modulated photons. We have demonstrated in vitro detection of ultrasound-modulated photons with a variety of detection methods. Furthermore, we have detected ultrasound-modulated fluorescence offering potential for acousto-optic molecular imaging. Moreover, we have demonstrated the use of ultrasound microbubbles to significantly enhance the acousto-optic signal at the ultrasound frequency with the additional generation of higher order harmonic frequencies. Here the results from our various detection methods, ultrasound-modulated fluorescence, and enhancement with microbubbles are presented.

AB - In vivo acousto-optic imaging promises to provide optical contrast at superior ultrasound spatial resolution. The main challenge is to detect ultrasound-modulated photons in the overwhelming presence of un-modulated photons. We have demonstrated in vitro detection of ultrasound-modulated photons with a variety of detection methods. Furthermore, we have detected ultrasound-modulated fluorescence offering potential for acousto-optic molecular imaging. Moreover, we have demonstrated the use of ultrasound microbubbles to significantly enhance the acousto-optic signal at the ultrasound frequency with the additional generation of higher order harmonic frequencies. Here the results from our various detection methods, ultrasound-modulated fluorescence, and enhancement with microbubbles are presented.

KW - Acousto-optic

KW - Fluorescence

KW - Microbubbles

KW - Ultrasound-modulated photons

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JO - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

JF - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

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Y2 - 25 January 2009 through 28 January 2009

ER -

Detection of ultrasound-modulated photons and enhancement with ultrasound microbubbles

Abstract

Keywords

ASJC Scopus subject areas

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