Detection of ultrasound-modulated photons and enhancement with ultrasound microbubbles

David J. Hall, Mark J. Hsu, Sadik Esener, Robert F. Mattrey

Research output: Contribution to journalConference articlepeer-review

3 Scopus citations


In vivo acousto-optic imaging promises to provide optical contrast at superior ultrasound spatial resolution. The main challenge is to detect ultrasound-modulated photons in the overwhelming presence of un-modulated photons. We have demonstrated in vitro detection of ultrasound-modulated photons with a variety of detection methods. Furthermore, we have detected ultrasound-modulated fluorescence offering potential for acousto-optic molecular imaging. Moreover, we have demonstrated the use of ultrasound microbubbles to significantly enhance the acousto-optic signal at the ultrasound frequency with the additional generation of higher order harmonic frequencies. Here the results from our various detection methods, ultrasound-modulated fluorescence, and enhancement with microbubbles are presented.

Original languageEnglish (US)
Article number71771L
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
StatePublished - 2009
Externally publishedYes
EventPhotons Plus Ultrasound: Imaging and Sensing 2009 - San Jose, CA, United States
Duration: Jan 25 2009Jan 28 2009


  • Acousto-optic
  • Fluorescence
  • Microbubbles
  • Ultrasound-modulated photons

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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