TY - JOUR
T1 - Determinants and functional impact of restrictive physiology after repair of tetralogy of Fallot
T2 - New insights from magnetic resonance imaging
AU - Lee, Whal
AU - Yoo, Shi Joon
AU - Roche, Susan L.
AU - Kantor, Paul
AU - Van Arsdell, Glen
AU - Park, Eun Ah
AU - Redington, Andrew
AU - Grosse-Wortmann, Lars
N1 - Funding Information:
Dr. Whal Lee was supported in part by grant no. A100131 from the Korean Ministry of Health and Welfare and Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education, Science and Technology(MEST) ( K21002001824-11E0100-02910 ) (Seoul, Korea).
PY - 2013/8/20
Y1 - 2013/8/20
N2 - Background: The presence of end-diastolic forward flow (EDFF) in the pulmonary arteries is commonly regarded as a hallmark of restrictive physiology of the right ventricle (RV) which, in turn, has been associated with a better long-term prognosis in patients after TOF repair. However, controversy persists over the beneficial clinical consequences of restrictive physiology. We aimed at determining the clinical relevance of restrictive physiology late after TOF repair. Methods: Fifty magnetic resonance examinations of 50 patients (age 13.0 ± 2.8 years, 26 males) with repaired TOF were evaluated. The patients were divided into: Group-1 with and Group-2 without EDFF; Group-A with smaller RVs (< 170 ml/m2) and Group-B with larger RVs (≥ 170 ml/m2). Maximum oxygen consumption as percent of predicted (VO2max-pred) at a recent exercise test was recorded. Results: Groups-1 and 2 did not differ with regard to their right ventricular end-diastolic volume, pulmonary regurgitant volume, or QRS duration. Patients in Group-1 had a higher VO2max-pred than patients in Group-2 (70.3% versus 54.7% of predicted, p < 0.01). In Group-1A versus 2A (RV < 170 ml/m2, with and without EDFF) this difference persisted, but in Group B there was no difference in VO2max-pred between patients with and without EDFF. The flow volume of EDFF correlated with VO2max-pred (r = 0.444, p = 0.007). Conclusions: End-diastolic forward flow measured by magnetic resonance is present in patients with small and large RVs. The presence of EDFF is associated with better exercise tolerance, but only in patients with relatively small RVs.
AB - Background: The presence of end-diastolic forward flow (EDFF) in the pulmonary arteries is commonly regarded as a hallmark of restrictive physiology of the right ventricle (RV) which, in turn, has been associated with a better long-term prognosis in patients after TOF repair. However, controversy persists over the beneficial clinical consequences of restrictive physiology. We aimed at determining the clinical relevance of restrictive physiology late after TOF repair. Methods: Fifty magnetic resonance examinations of 50 patients (age 13.0 ± 2.8 years, 26 males) with repaired TOF were evaluated. The patients were divided into: Group-1 with and Group-2 without EDFF; Group-A with smaller RVs (< 170 ml/m2) and Group-B with larger RVs (≥ 170 ml/m2). Maximum oxygen consumption as percent of predicted (VO2max-pred) at a recent exercise test was recorded. Results: Groups-1 and 2 did not differ with regard to their right ventricular end-diastolic volume, pulmonary regurgitant volume, or QRS duration. Patients in Group-1 had a higher VO2max-pred than patients in Group-2 (70.3% versus 54.7% of predicted, p < 0.01). In Group-1A versus 2A (RV < 170 ml/m2, with and without EDFF) this difference persisted, but in Group B there was no difference in VO2max-pred between patients with and without EDFF. The flow volume of EDFF correlated with VO2max-pred (r = 0.444, p = 0.007). Conclusions: End-diastolic forward flow measured by magnetic resonance is present in patients with small and large RVs. The presence of EDFF is associated with better exercise tolerance, but only in patients with relatively small RVs.
KW - Magnetic resonance imaging
KW - Restrictive physiology
KW - Tetralogy of Fallot
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U2 - 10.1016/j.ijcard.2012.04.008
DO - 10.1016/j.ijcard.2012.04.008
M3 - Article
C2 - 22537978
AN - SCOPUS:84881475826
SN - 0167-5273
VL - 167
SP - 1347
EP - 1353
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 4
ER -