TY - JOUR
T1 - Determination of thermal and physical properties of port wine stain lesions using pulsed photothermal radiometry
AU - Nelson, J. S.
AU - Jacques, S. L.
AU - Wright, W. H.
N1 - Funding Information:
This study was supported by a Biomedical Engineering Research Grant from the Whitaker Foundation to JSN and a grant from the NIH (R29-45045) to SLJ. Support was also provided by grants from the Department of Energy (DE- FGO3-91ER61227) and the Office of Naval Research (N00014-91-C-0134) to Michael W. Berns. The authors gratefully acknowledge his role in placing the research facilities and support personnel at the Beckman Laser Institute and Medical Clinic at their disposal.
Publisher Copyright:
© 1992 SPIE. All rights reserved.
PY - 1992/6/1
Y1 - 1992/6/1
N2 - A method for quantitative characterization of port wine slain (PWS) is presented. Pulsed photothermal radiometry (PPTR) uses a non-invasive infrared radiometry system to measure changes in surface temperature induced by pulsed radiation. When a pulsed laser is used to irradiate a PWS, an initial temperature jump (T-jump) is seen due to the heating of the epidermis as a result of melanin absorption. Subsequently, heat generated in the subsurface blood vessels due to hemoglobin absorption is detected by PPTR as a delayed thermal wave as the heat diffuses toward the skin surface. The time delay and magnitude of the delayed PPTR signal indicate the depth and thickness of the PWS. In this report, we present an initial clinical study of PPTR measurements on PWS patients. Computer simulations of various classes of PWS illustrate how the PPTR signal depends on the concentration of epidermal melanin, and depth and thickness of the PWS. The goal of this research is to provide a means of characterizing PWS before initialing therapy, guiding laser dosimetry, and advising the palient as to the time course and efficacy of the planned protocol.
AB - A method for quantitative characterization of port wine slain (PWS) is presented. Pulsed photothermal radiometry (PPTR) uses a non-invasive infrared radiometry system to measure changes in surface temperature induced by pulsed radiation. When a pulsed laser is used to irradiate a PWS, an initial temperature jump (T-jump) is seen due to the heating of the epidermis as a result of melanin absorption. Subsequently, heat generated in the subsurface blood vessels due to hemoglobin absorption is detected by PPTR as a delayed thermal wave as the heat diffuses toward the skin surface. The time delay and magnitude of the delayed PPTR signal indicate the depth and thickness of the PWS. In this report, we present an initial clinical study of PPTR measurements on PWS patients. Computer simulations of various classes of PWS illustrate how the PPTR signal depends on the concentration of epidermal melanin, and depth and thickness of the PWS. The goal of this research is to provide a means of characterizing PWS before initialing therapy, guiding laser dosimetry, and advising the palient as to the time course and efficacy of the planned protocol.
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U2 - 10.1117/12.137357
DO - 10.1117/12.137357
M3 - Conference article
AN - SCOPUS:84968260980
SN - 0277-786X
VL - 1643
SP - 287
EP - 298
JO - Proceedings of SPIE - The International Society for Optical Engineering
JF - Proceedings of SPIE - The International Society for Optical Engineering
T2 - Laser Surgery: Advanced Characterization, Therapeutics, and Systems III 1992
Y2 - 19 January 1992 through 24 January 1992
ER -