TY - JOUR
T1 - Development of Proanthocyanidin-Loaded Mesoporous Silica Nanoparticles for Improving Dental Adhesion
AU - Alkhazaleh, Ahmad
AU - Elfagih, Sundes
AU - Chakka, Leela Raghava Jaidev
AU - Armstrong, Steven R.
AU - Comnick, Carissa L.
AU - Qian, Fang
AU - Salem, Aliasger K.
AU - Guymon, C. Allan
AU - Haes, Amanda J.
AU - Vidal, Cristina M.P.
N1 - Publisher Copyright:
© 2022 American Chemical Society. All rights reserved.
PY - 2022/12/5
Y1 - 2022/12/5
N2 - Dentin biomodification is a promising approach to enhance dental tissue biomechanics and biostability for restorative and reparative therapies. One of the most active dentin tissue biomodifiers is proanthocyanidin (PAC)-rich natural extracts, which are used in the dental bonding procedure in combination with resin-based adhesives (RBAs). This study aimed to investigate the use of mesoporous silica nanoparticles (MSNs) for the sustained delivery of PACs for dentin biomodification as a novel drug-delivery system for dental applications. The effects of the incorporation of MSN functionalized with 3-aminopropyltriethoxysilane (APTES) and loaded with PAC into an experimental RBA were assessed by characterizing the material mechanical properties. In addition, the immediate and long-term bonding performance of an experimental resin-based primer (RBP) containing MSN-APTES loaded with PAC was also evaluated. For that, different formulations of RBA and RBP were prepared containing 20% w/v MSN-APTES loaded with PAC before or after functionalization (MSN-PAC-APTES and MSN-APTES-PAC, respectively). The incorporation of MSN-APTES-PAC did not negatively impact the degree of conversion or the overall mechanical properties of the RBA. However, adding MSN-PAC-APTES resulted in inferior mechanical properties of the experimental RBA. In the adhesion studies, APTES-functionalized MSN was successfully added to an experimental RBP for drug-delivery purposes without compromising the bond strength to the dentin or the failure mode. Interestingly, the sequence of surface functionalization with APTES resulted in differences in the bonding performance, with better long-term results for RBP containing MSN loaded with PAC after functionalization.
AB - Dentin biomodification is a promising approach to enhance dental tissue biomechanics and biostability for restorative and reparative therapies. One of the most active dentin tissue biomodifiers is proanthocyanidin (PAC)-rich natural extracts, which are used in the dental bonding procedure in combination with resin-based adhesives (RBAs). This study aimed to investigate the use of mesoporous silica nanoparticles (MSNs) for the sustained delivery of PACs for dentin biomodification as a novel drug-delivery system for dental applications. The effects of the incorporation of MSN functionalized with 3-aminopropyltriethoxysilane (APTES) and loaded with PAC into an experimental RBA were assessed by characterizing the material mechanical properties. In addition, the immediate and long-term bonding performance of an experimental resin-based primer (RBP) containing MSN-APTES loaded with PAC was also evaluated. For that, different formulations of RBA and RBP were prepared containing 20% w/v MSN-APTES loaded with PAC before or after functionalization (MSN-PAC-APTES and MSN-APTES-PAC, respectively). The incorporation of MSN-APTES-PAC did not negatively impact the degree of conversion or the overall mechanical properties of the RBA. However, adding MSN-PAC-APTES resulted in inferior mechanical properties of the experimental RBA. In the adhesion studies, APTES-functionalized MSN was successfully added to an experimental RBP for drug-delivery purposes without compromising the bond strength to the dentin or the failure mode. Interestingly, the sequence of surface functionalization with APTES resulted in differences in the bonding performance, with better long-term results for RBP containing MSN loaded with PAC after functionalization.
KW - Dental Adhesion
KW - Dental Adhesives
KW - Dentin
KW - Dentin Biomodification
KW - Mesoporous Silica Nanoparticles
KW - Proanthocyanidins
UR - http://www.scopus.com/inward/record.url?scp=85141986470&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85141986470&partnerID=8YFLogxK
U2 - 10.1021/acs.molpharmaceut.2c00728
DO - 10.1021/acs.molpharmaceut.2c00728
M3 - Article
C2 - 36349888
AN - SCOPUS:85141986470
SN - 1543-8384
VL - 19
SP - 4675
EP - 4684
JO - Molecular Pharmaceutics
JF - Molecular Pharmaceutics
IS - 12
ER -