Diabetes-related changes in auditory brainstem responses

Dawn Konrad-Martin, Donald F. Austin, Susan Griest, Garnett P. McMillan, Daniel McDermott, Stephen Fausti

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Objectives/Hypothesis: Determine effects on auditory brainstem response (ABR) of diabetes mellitus (DM) severity. Study Design: A cross-sectional study investigating DM severity and ABR in military Veteran subjects with (166) and without (138) DM and with no more than moderate hearing loss. Methods: Subjects were classified by three age tertiles (<50, 50-56, and 57+). DM severity was classified as insulin-dependent (IDDM), non-insulindependent (NIDDM), or no DM. Other DM measures included serum glucose, HbA1c, and several DMrelated complications. ABR measures included wave I, III, and V latencies; I-III, III-V, and I-V latency intervals; and wave V amplitude; for each ear at three repetition rates (11, 51, and 71 clicks/second), and both polarities. Outcomes were stratified by age tertile and adjusted for pure tone threshold at 3 kHz. Repeated measures multivariate analysis of covariance modeled the ABR response at each repetition rate for DM severity (main effect) and hearing at 3 kHz (covariate). Modeled contrasts between ABR variables in subjects with and without DM were examined. Results: Significant differences existed between no DM and IDDM groups in the younger tertile only. Adjusting for threshold at 3 kHz had minimal effect. Self-reported noise exposure was not related to ABR differences, but HbA1c and poor circulation were. Conclusions: IDDM is associated with an increased wave V latency, wave I-V interval, and reduced wave V amplitude among Veterans under 50 years. Results were related to several DM complications.

Original languageEnglish (US)
Pages (from-to)150-158
Number of pages9
Issue number1
StatePublished - Jan 2010
Externally publishedYes


  • Auditory brainstem response
  • Diabetes
  • Hearing loss
  • Veterans

ASJC Scopus subject areas

  • Otorhinolaryngology


Dive into the research topics of 'Diabetes-related changes in auditory brainstem responses'. Together they form a unique fingerprint.

Cite this