TY - JOUR
T1 - Diabetes-related changes in auditory brainstem responses
AU - Konrad-Martin, Dawn
AU - Austin, Donald F.
AU - Griest, Susan
AU - McMillan, Garnett P.
AU - McDermott, Daniel
AU - Fausti, Stephen
PY - 2010/1
Y1 - 2010/1
N2 - Objectives/Hypothesis: Determine effects on auditory brainstem response (ABR) of diabetes mellitus (DM) severity. Study Design: A cross-sectional study investigating DM severity and ABR in military Veteran subjects with (166) and without (138) DM and with no more than moderate hearing loss. Methods: Subjects were classified by three age tertiles (<50, 50-56, and 57+). DM severity was classified as insulin-dependent (IDDM), non-insulindependent (NIDDM), or no DM. Other DM measures included serum glucose, HbA1c, and several DMrelated complications. ABR measures included wave I, III, and V latencies; I-III, III-V, and I-V latency intervals; and wave V amplitude; for each ear at three repetition rates (11, 51, and 71 clicks/second), and both polarities. Outcomes were stratified by age tertile and adjusted for pure tone threshold at 3 kHz. Repeated measures multivariate analysis of covariance modeled the ABR response at each repetition rate for DM severity (main effect) and hearing at 3 kHz (covariate). Modeled contrasts between ABR variables in subjects with and without DM were examined. Results: Significant differences existed between no DM and IDDM groups in the younger tertile only. Adjusting for threshold at 3 kHz had minimal effect. Self-reported noise exposure was not related to ABR differences, but HbA1c and poor circulation were. Conclusions: IDDM is associated with an increased wave V latency, wave I-V interval, and reduced wave V amplitude among Veterans under 50 years. Results were related to several DM complications.
AB - Objectives/Hypothesis: Determine effects on auditory brainstem response (ABR) of diabetes mellitus (DM) severity. Study Design: A cross-sectional study investigating DM severity and ABR in military Veteran subjects with (166) and without (138) DM and with no more than moderate hearing loss. Methods: Subjects were classified by three age tertiles (<50, 50-56, and 57+). DM severity was classified as insulin-dependent (IDDM), non-insulindependent (NIDDM), or no DM. Other DM measures included serum glucose, HbA1c, and several DMrelated complications. ABR measures included wave I, III, and V latencies; I-III, III-V, and I-V latency intervals; and wave V amplitude; for each ear at three repetition rates (11, 51, and 71 clicks/second), and both polarities. Outcomes were stratified by age tertile and adjusted for pure tone threshold at 3 kHz. Repeated measures multivariate analysis of covariance modeled the ABR response at each repetition rate for DM severity (main effect) and hearing at 3 kHz (covariate). Modeled contrasts between ABR variables in subjects with and without DM were examined. Results: Significant differences existed between no DM and IDDM groups in the younger tertile only. Adjusting for threshold at 3 kHz had minimal effect. Self-reported noise exposure was not related to ABR differences, but HbA1c and poor circulation were. Conclusions: IDDM is associated with an increased wave V latency, wave I-V interval, and reduced wave V amplitude among Veterans under 50 years. Results were related to several DM complications.
KW - Auditory brainstem response
KW - Diabetes
KW - Hearing loss
KW - Veterans
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U2 - 10.1002/lary.20636
DO - 10.1002/lary.20636
M3 - Article
C2 - 19904812
AN - SCOPUS:74049135726
SN - 0023-852X
VL - 120
SP - 150
EP - 158
JO - Laryngoscope
JF - Laryngoscope
IS - 1
ER -