Diabetic nephropathy and proximal tubule ROS: Challenging our glomerulocentricity

S. P. Bagby

doi:10.1038/sj.ki.5002286

Diabetic nephropathy and proximal tubule ROS: Challenging our glomerulocentricity

S. P. Bagby

Research output: Contribution to journal › Comment/debate › peer-review

39 Scopus citations

Abstract

Diabetic nephropathy is currently viewed as a predominantly glomerular process with glomerular injury driving secondary tubular loss. Brezniceanu and colleagues apply transgenic methods to support a prominent role for reactive oxygen species as mediators and for the proximal tubule as a major site of early disease activity in diabetes. Results support evidence for early tubular apoptosis and atrophy in human diabetic nephropathy.

Original language	English (US)
Pages (from-to)	1199-1202
Number of pages	4
Journal	Kidney International
Volume	71
Issue number	12
DOIs	https://doi.org/10.1038/sj.ki.5002286
State	Published - Jun 2007
Externally published	Yes

ASJC Scopus subject areas

Nephrology

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10.1038/sj.ki.5002286

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title = "Diabetic nephropathy and proximal tubule ROS: Challenging our glomerulocentricity",

abstract = "Diabetic nephropathy is currently viewed as a predominantly glomerular process with glomerular injury driving secondary tubular loss. Brezniceanu and colleagues apply transgenic methods to support a prominent role for reactive oxygen species as mediators and for the proximal tubule as a major site of early disease activity in diabetes. Results support evidence for early tubular apoptosis and atrophy in human diabetic nephropathy.",

author = "Bagby, {S. P.}",

year = "2007",

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AB - Diabetic nephropathy is currently viewed as a predominantly glomerular process with glomerular injury driving secondary tubular loss. Brezniceanu and colleagues apply transgenic methods to support a prominent role for reactive oxygen species as mediators and for the proximal tubule as a major site of early disease activity in diabetes. Results support evidence for early tubular apoptosis and atrophy in human diabetic nephropathy.

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DO - 10.1038/sj.ki.5002286

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JO - Kidney International

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Diabetic nephropathy and proximal tubule ROS: Challenging our glomerulocentricity

Abstract

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