Dietary copper and copper dependant superoxide dismutase in hepatic prostaglandin synthesis by rat liver homogenates

Kirsten J. Lampi; Melvin M. Mathias; Bruce D. Rengers; Kenneth G.D. Allen

doi:10.1016/S0271-5317(88)80120-9

Dietary copper and copper dependant superoxide dismutase in hepatic prostaglandin synthesis by rat liver homogenates

Kirsten J. Lampi, Melvin M. Mathias, Bruce D. Rengers, Kenneth G.D. Allen

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The influence of dietary copper, Cu²⁺ additions and Cu/Zn SOD additions on liver homogenate PGE2 and PGF2α production was examined in rats. Dietary copper deficiency significantly decreased both PGE2 and PGF2α synthesis in liver homogenates. Cu²⁺ additions to 10 μM or 100 μM (final) had no effect on PGE2 or PGF2α synthesis in either deficient or control liver homogenates. Addition of purified Cu/Zn SOD to a concentration approximately equal to that of control liver, significantly increased PGE2 and PGF2α synthesis in both control and copper deficient liver homogenates. Addition of purified Cu/Zn SOD to a concentration approximately three times that of control liver significantly depressed PGE2 and PGF2α synthesis in copper-deficient liver homogenates. In all cases addition of arachidonic acid (100 μM, final) had no influence on the above listed responses. Both PGE2 and PGF2α production by liver homogenates showed a significant correlation with SOD. Both dietary copper and added Cu/Zn SOD, but not added Cu²⁺, influence PGE2 and PGF2α production in liver homogenates.

Original language	English (US)
Pages (from-to)	1191-1202
Number of pages	12
Journal	Nutrition Research
Volume	8
Issue number	10
DOIs	https://doi.org/10.1016/S0271-5317(88)80120-9
State	Published - Oct 1988
Externally published	Yes

Keywords

copper
prostaglandins
superoxide dismutase

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Nutrition and Dietetics

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10.1016/S0271-5317(88)80120-9

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title = "Dietary copper and copper dependant superoxide dismutase in hepatic prostaglandin synthesis by rat liver homogenates",

abstract = "The influence of dietary copper, Cu2+ additions and Cu/Zn SOD additions on liver homogenate PGE2 and PGF2α production was examined in rats. Dietary copper deficiency significantly decreased both PGE2 and PGF2α synthesis in liver homogenates. Cu2+ additions to 10 μM or 100 μM (final) had no effect on PGE2 or PGF2α synthesis in either deficient or control liver homogenates. Addition of purified Cu/Zn SOD to a concentration approximately equal to that of control liver, significantly increased PGE2 and PGF2α synthesis in both control and copper deficient liver homogenates. Addition of purified Cu/Zn SOD to a concentration approximately three times that of control liver significantly depressed PGE2 and PGF2α synthesis in copper-deficient liver homogenates. In all cases addition of arachidonic acid (100 μM, final) had no influence on the above listed responses. Both PGE2 and PGF2α production by liver homogenates showed a significant correlation with SOD. Both dietary copper and added Cu/Zn SOD, but not added Cu2+, influence PGE2 and PGF2α production in liver homogenates.",

keywords = "copper, prostaglandins, superoxide dismutase",

author = "Lampi, {Kirsten J.} and Mathias, {Melvin M.} and Rengers, {Bruce D.} and Allen, {Kenneth G.D.}",

year = "1988",

month = oct,

doi = "10.1016/S0271-5317(88)80120-9",

language = "English (US)",

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pages = "1191--1202",

journal = "Nutrition Research",

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T1 - Dietary copper and copper dependant superoxide dismutase in hepatic prostaglandin synthesis by rat liver homogenates

AU - Lampi, Kirsten J.

AU - Mathias, Melvin M.

AU - Rengers, Bruce D.

AU - Allen, Kenneth G.D.

PY - 1988/10

Y1 - 1988/10

N2 - The influence of dietary copper, Cu2+ additions and Cu/Zn SOD additions on liver homogenate PGE2 and PGF2α production was examined in rats. Dietary copper deficiency significantly decreased both PGE2 and PGF2α synthesis in liver homogenates. Cu2+ additions to 10 μM or 100 μM (final) had no effect on PGE2 or PGF2α synthesis in either deficient or control liver homogenates. Addition of purified Cu/Zn SOD to a concentration approximately equal to that of control liver, significantly increased PGE2 and PGF2α synthesis in both control and copper deficient liver homogenates. Addition of purified Cu/Zn SOD to a concentration approximately three times that of control liver significantly depressed PGE2 and PGF2α synthesis in copper-deficient liver homogenates. In all cases addition of arachidonic acid (100 μM, final) had no influence on the above listed responses. Both PGE2 and PGF2α production by liver homogenates showed a significant correlation with SOD. Both dietary copper and added Cu/Zn SOD, but not added Cu2+, influence PGE2 and PGF2α production in liver homogenates.

AB - The influence of dietary copper, Cu2+ additions and Cu/Zn SOD additions on liver homogenate PGE2 and PGF2α production was examined in rats. Dietary copper deficiency significantly decreased both PGE2 and PGF2α synthesis in liver homogenates. Cu2+ additions to 10 μM or 100 μM (final) had no effect on PGE2 or PGF2α synthesis in either deficient or control liver homogenates. Addition of purified Cu/Zn SOD to a concentration approximately equal to that of control liver, significantly increased PGE2 and PGF2α synthesis in both control and copper deficient liver homogenates. Addition of purified Cu/Zn SOD to a concentration approximately three times that of control liver significantly depressed PGE2 and PGF2α synthesis in copper-deficient liver homogenates. In all cases addition of arachidonic acid (100 μM, final) had no influence on the above listed responses. Both PGE2 and PGF2α production by liver homogenates showed a significant correlation with SOD. Both dietary copper and added Cu/Zn SOD, but not added Cu2+, influence PGE2 and PGF2α production in liver homogenates.

KW - copper

KW - prostaglandins

KW - superoxide dismutase

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SN - 0271-5317

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JO - Nutrition Research

JF - Nutrition Research

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ER -

Dietary copper and copper dependant superoxide dismutase in hepatic prostaglandin synthesis by rat liver homogenates

Abstract

Keywords

ASJC Scopus subject areas

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