Differences in brachial and femoral artery responses to prolonged sitting

Saurabh S. Thosar, Sylvanna L. Bielko, Chad C. Wiggins, Janet P. Wallace

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Introduction: It is unknown if there are limb differences in vascular function during prolonged sitting. Purpose: This study was designed to test whether the effects of prolonged sitting on brachial artery (BA) and the superficial femoral artery (SFA) are similar. Methods: Twelve men (24.2 ± 4 yrs.) participated in a 3 hr prolonged sitting trial (SIT). SFA and BA flow mediated dilation (FMD) and respective flow patterns were measured at baseline, 1 hr, 2 hr and 3 hr. Results: By a one-way ANOVA there was a significant decline in SFA FMD during 3 hrs of SIT (p < 0.001). Simultaneously, there was a significant decline in antegrade (p = 0.04) and mean (0.037) shear rates. By a one way ANOVA there were no significant differences in BA FMD during 3 hrs of sitting. There were no changes in the shear rates in the BA except for a significant decrease in antegrade shear rate (p = 0.029) and a significant increase in oscillatory shear index (p = 0.034) during 3 hrs of sitting. Furthermore, there was no correlation between BA and SFA FMD measurements. Conclusion: Three hours of sitting resulted in impaired SFA FMD but not BA FMD. Although 3 hours of sitting did not impair BA FMD, it impaired shear patterns in the BA.

Original languageEnglish (US)
Article number50
JournalCardiovascular Ultrasound
Issue number1
StatePublished - 2014


  • Flow mediated dilation
  • Limb differences
  • Prolonged sitting
  • Sedentary

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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