Direct delivery of anticancer agents: Experimental treatment of intraocular malignancy

H. S. Liu, M. F. Refojo, H. D. Perry, D. M. Albert

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Two anticancer agents, one lipophilic, 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), and one hydrophilic, 5-(3,3-dimethyl-1-triazeno) imidazol-4-carboxamide (DTIC), were used to treat Brown-Pearce epithelioma in the anterior chamber of rabbit eyes. The BCNU test animals were divided into three groups: one treated by direct injection of the drug into the subconjunctival space or the anterior chamber, the second by both direct injection and intravenous administration, and the third by intravenous injection alone. The DTIC test animals were treated with only local injection into the subconjunctival space or anterior chamber. Dosage, delivery system, and effectiveness were compared following clinical observation and histopathologic examination. Direct delivery of BCNU or DTIC in subconjunctival space or anterior chamber delayed the growth of Brown-Pearce epithelioma in rabbit eye. The effectiveness of this treatment was significantly enhanced by combining direct injection with systemic administration of a lower dose of BCNU.

Original languageEnglish (US)
Pages (from-to)993-1004
Number of pages12
JournalInvestigative Ophthalmology and Visual Science
Issue number10
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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