Discontinuing clozapine: An example of explicit health care rationing

Bentson H. McFariand

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Clozapine's efficacy, side effect profile, and cost raise numerous clinical, administrative, and ethical concerns. The author presents mathematical models to determine the optimal time for an efficacy evaluation. The models are based on the presumption that clinical considerations as well as limited resources will preclude treating for an indefinite length of time a person who has not shown improvement. This quantitative approach to decision making also suggests what types of data should be obtained in future research on clozapine.

Original languageEnglish (US)
Pages (from-to)399-416
Number of pages18
JournalAdministration and Policy in Mental Health
Issue number6
StatePublished - Jul 1992
Externally publishedYes

ASJC Scopus subject areas

  • Phychiatric Mental Health
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health


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