@article{0ee3385be80f4acfa44500753227e838,
title = "Disposable aptamer-sensor aided by magnetic nanoparticle enrichment for detection of salivary cortisol variations in obstructive sleep apnea patients",
abstract = "We report a disposable point-of-care sensing platform specific to salivary cortisol detection. The sensor is inkjet printed on a paper substrate with a metalloporphyrin based macrocyclic catalyst ink that can electrochemically reduce cortisol, captured by aptamer functionalized magnetic nanoparticles. The sensor consists of a thin magnet disc, aligned at the back of the electrode, in order to populate the magnetic nanoparticle bound cortisol at the sensing electrode area. Proof of concept studies were performed to detect salivary cortisol levels in human subjects with high and low risks for obstructive sleep apnea (OSA). High selectivity was observed to salivary cortisol against a background of closely related steroids.",
author = "Fernandez, {Renny Edwin} and Yogeswaran Umasankar and Pandiaraj Manickam and Nickel, {Jeffrey C.} and Iwasaki, {Laura R.} and Kawamoto, {Burt K.} and Todoki, {Kristen C.} and Scott, {Jo Anna M.} and Shekhar Bhansali",
note = "Funding Information: The authors wish to acknowledge the research grants from School of Dentistry Rinehart Foundation - University of Missouri-Kansas City, Award #1602, NSF Nanosystems Engineering Research Center for Advanced Self-Powered Systems of Integrated Sensors and Technologies (ASSIST), Award #1160483. The subjects all gave written consent to participate in protocol #16-259, approved by the University of Missouri-Kansas City Institutional Review Board. Publisher Copyright: {\textcopyright} 2017 The Author(s).",
year = "2017",
month = dec,
day = "1",
doi = "10.1038/s41598-017-17835-8",
language = "English (US)",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}