DNA mismatch repair deficiency in curatively resected sextuple primary cancers in different organs: A molecular case report

Hiroyuki Yakushiji; Shinsuke Mukai; Shiroh Matsukura; Seiji Sato; Akiomi Ogawa; Eizaburo Sasatomi; Kohji Miyazaki

doi:10.1016/S0304-3835(99)00110-X

DNA mismatch repair deficiency in curatively resected sextuple primary cancers in different organs: A molecular case report

Hiroyuki Yakushiji, Shinsuke Mukai, Shiroh Matsukura, Seiji Sato, Akiomi Ogawa, Eizaburo Sasatomi, Kohji Miyazaki

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A male patient synchronously or metachronously underwent six curative resections after diagnoses of cancers in the rectum, urinary bladder, stomach, colon, liver and lung. Five cancers, excluding early colon cancer, were analyzed for instability in seven microsatellite markers and in transforming growth factor β type II receptor, insulin-like growth factor II receptor and BAX. All analyzed cancers had replication errors and instability in at least one target gene. These results suggest that abnormal DNA mismatch repair system plays a major role in the occurrence of multiple primary cancers in this case. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	17-22
Number of pages	6
Journal	Cancer Letters
Volume	142
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(99)00110-X
State	Published - Jul 19 1999
Externally published	Yes

Keywords

DNA mismatch repair deficiency
Microsatellite instability
Multiple primary cancers
Replication error

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/S0304-3835(99)00110-X

Cite this

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title = "DNA mismatch repair deficiency in curatively resected sextuple primary cancers in different organs: A molecular case report",

abstract = "A male patient synchronously or metachronously underwent six curative resections after diagnoses of cancers in the rectum, urinary bladder, stomach, colon, liver and lung. Five cancers, excluding early colon cancer, were analyzed for instability in seven microsatellite markers and in transforming growth factor β type II receptor, insulin-like growth factor II receptor and BAX. All analyzed cancers had replication errors and instability in at least one target gene. These results suggest that abnormal DNA mismatch repair system plays a major role in the occurrence of multiple primary cancers in this case. Copyright (C) 1999 Elsevier Science Ireland Ltd.",

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T1 - DNA mismatch repair deficiency in curatively resected sextuple primary cancers in different organs

T2 - A molecular case report

AU - Yakushiji, Hiroyuki

AU - Mukai, Shinsuke

AU - Matsukura, Shiroh

AU - Sato, Seiji

AU - Ogawa, Akiomi

AU - Sasatomi, Eizaburo

AU - Miyazaki, Kohji

PY - 1999/7/19

Y1 - 1999/7/19

N2 - A male patient synchronously or metachronously underwent six curative resections after diagnoses of cancers in the rectum, urinary bladder, stomach, colon, liver and lung. Five cancers, excluding early colon cancer, were analyzed for instability in seven microsatellite markers and in transforming growth factor β type II receptor, insulin-like growth factor II receptor and BAX. All analyzed cancers had replication errors and instability in at least one target gene. These results suggest that abnormal DNA mismatch repair system plays a major role in the occurrence of multiple primary cancers in this case. Copyright (C) 1999 Elsevier Science Ireland Ltd.

AB - A male patient synchronously or metachronously underwent six curative resections after diagnoses of cancers in the rectum, urinary bladder, stomach, colon, liver and lung. Five cancers, excluding early colon cancer, were analyzed for instability in seven microsatellite markers and in transforming growth factor β type II receptor, insulin-like growth factor II receptor and BAX. All analyzed cancers had replication errors and instability in at least one target gene. These results suggest that abnormal DNA mismatch repair system plays a major role in the occurrence of multiple primary cancers in this case. Copyright (C) 1999 Elsevier Science Ireland Ltd.

KW - DNA mismatch repair deficiency

KW - Microsatellite instability

KW - Multiple primary cancers

KW - Replication error

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DNA mismatch repair deficiency in curatively resected sextuple primary cancers in different organs: A molecular case report

Abstract

Keywords

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